水飞蓟素固体分散体的制备及5种成分的溶出度  

Preparation of silymarin solid dispersions and dissolution rates of five constituents

作　　者：孙欣荣[1,2] 张敏新[2] 杨海跃[2,3] 吴珏 宋洪涛[2] 刘志宏[2] 

机构地区：[1]福建中医药大学药学院,福建福州350122 [2]福州总医院药学科,福建福州350025 [3]厦门大学医学院,福建厦门361102

出　　处：《中成药》2018年第1期87-92,共6页Chinese Traditional Patent Medicine

基　　金：福建省自然科学基金项目(2015J01491)

摘　　要：目的制备水飞蓟素固体分散体,并评价5种成分的溶出度。方法以F68与PVPk30为联合载体,溶剂熔融法制备固体分散体。再考察联合载体比例、药物-载体比例对水飞蓟宾、异水飞蓟宾、水飞蓟宁、水飞蓟亭、花旗松素溶出度的影响。结果最佳条件为联合载体比例1∶3,药物-载体比例1∶5。固体分散体中5种成分的溶出度显著高于原料药和物理混合物(水飞蓟素-载体)中。结论固体分散体可显著提高水飞蓟素中有效成分的溶出度。AIM To prepare silymarin solid dispersions and to evaluate the dissolution rates of five constitu- ents. METHODS Taking 1768 and PVPk30 as a combined carrier, the solid dispersions were prepared by solvent fusion method. Then the effects of combined carrier ratio and drug-carrier ratio on dissolution rates of silybin, isosi- lybin, silydianin, silycristin and taxifolin were investigated. RESULTS The optimal conditions were determined to be 1 ： 3 for combined carrier ratio, and 1 ： 5 for drug-carrier ratio. These five constituents displayed much higher dissolution rates in solid dispersions than those in raw medicine and physical mixture （silymarin-carrier）. CONCLUSION Solid dispersions can significantly increase the dissolution rates of effective components in sily-marin.

关 键 词：水飞蓟素 固体分散体 制备 化学成分 溶出度 溶剂熔融法 

分 类 号：R944[医药卫生—药剂学]