生殖道HPV感染与阴道混合性感染相关危险因素的研究  

Risk Factors of Genital Tract HPV Infection and Vaginal Mixed Infection

作　　者：孟龄婷 高丽[1] 岳婷[1,3] 王俊侠 曾宪玲[1] 薛艳[1] 安瑞芳[1] 

机构地区：[1]西安交通大学第一附属医院,陕西西安710061 [2]西北妇女儿童医院,陕西西安710061 [3]陕西省人民医院,陕西西安710068

出　　处：《实用妇产科杂志》2018年第1期30-34,共5页Journal of Practical Obstetrics and Gynecology

基　　金：陕西省科技统筹创新计划(编号:2016KTCL03-06)

摘　　要：目的:探讨生殖道人乳头瘤病毒(HPV)感染与阴道混合性感染之间的相关危险因素。方法:对2015年6月至2016年10月就诊于西安交通大学第一附属医院妇科门诊,同时行阴道微生态及HPV分型检测的1914例患者的检查结果并进行分析。结果:1914例患者中,HPV感染率28.00%(536/1914)。1378例未感染HPV者中阴道感染性疾病发生率为55.88%(770/1378),536例HPV感染者中阴道感染性疾病的发生率为65.30%(350/536),HPV感染者较未感染者阴道感染性疾病的发生率高(P<0.05)。阴道微生态正常者HPV感染率为25.26%(97/384),阴道混合性感染者HPV感染率33.86%(64/189),阴道混合性感染者HPV感染率较阴道微生态正常者高(P<0.05)。以阴道微生态正常者为对照(OR=1),阴道混合性感染与HPV感染间的OR1=1.515(95%CI 1.037~2.213)。阴道微生态正常者HPV16/18感染率为7.55%(29/384),阴道混合性感染者HPV16/18感染率为17.99%(34/189),混合性感染者较阴道微生态正常者高(P<0.05)。以阴道微生态正常者为对照(OR=1),阴道混合性感染与HPV16/18感染间的OR2=2.685(95%CI 1.580~4.563)。结论:阴道混合性感染可增加HPV及HPV16/18的感染率,特别是可以增加HPV16/18的感染率。Objective： To explore the relationship between vaginal mixed Infection and HPV infection. Meth- ods：Data from 1914 outpatients who underwent the vaginal micro-ecology and HPV type detection during June 2015 to October 2016 were collected and analyzed in the first affiliated hospital of Xi＇an Jiaotong university. Re- sults： HPV positive rate in 1914 cases was 28% （536/1914）. The incidence of vaginal infectious disease in 1378 HPV uninfected patients was 55.88% （770/1378） ,while the incidence in 536 HPV infected patients was 65.30% （350/536） ,the incidence of vaginal infectious disease was higher in HPV infected patients （ P 〈 0.05）. HPV in- fection rate was 25.26% （97/384）in normal vaginal microecology, use normal vaginal microecology as controls, OR = 1, HPV infection rate was 33.86% （64/189） in vaginal mixed infection,χ2 = 4. 639, OR1 = 1. 515 （95% CI 1. 037 -2. 213）, HPV infection rate in mixed infection patients were significantly higher than in normal vaginal mi- croecology（P〈 0.05）;Of 91 cases high-risk type HPV infection in normal vaginal microecology, HPV16 and HPV18 infection account 31.87% （29/91） ,the positive rate was 7.55% （29/384）, use normal vaginal microecol- ogy as controls, OR = 1,59 cases high-risk type HPV infection were found in vaginal mixed infection patients, HPV16 and HPV18 infection account 57.62% （34/59） ,the positive rate was 17.99% （34/189） ,χ2 = 14. 100, OR2 =2. 685（95%CI 1. 580 -4. 563）. Conclusions：The vaginal mixed infection can increase the HPV infection rate, especially for HPV16 or HPV18.

关 键 词：阴道微生态 人乳头瘤病毒 阴道混合性感染 多样性 

分 类 号：R711.3[医药卫生—妇产科学]