慢性阻塞性肺疾病急性发作期患者治疗前后血清缺氧诱导因子1α及甘胆酸的检测分析  

Detection and analysis of serum HIF-1 alpha and CG of patient with COPD in acute stage before and after treatment

作　　者：赵乌云[1] 施金云 

机构地区：[1]内蒙古医科大学附属医院核医学科,内蒙古呼和浩特010050

出　　处：《中国医学装备》2018年第1期85-87,共3页China Medical Equipment

摘　　要：目的:研究血清甘胆酸(CG)与缺氧诱导因子1α(HIF-1α)检测在慢性阻塞性肺疾病(COPD)急性发作期患者的评估价值。方法:选择医院诊治的78例COPD急性发作期患者纳入观察组,另选取78名同期健康体检者纳入健康对照组。对比两组CG、HIF-1α表达,评估C反应蛋白(CRP)、白细胞介素-8(IL-8)和白细胞三烯B4(LTB4)在患者病情诊断中的作用及其临床价值。结果:观察组患者治疗前CG和CRP分别为(11.45±1.28)mg/L和(28.68±3.63)mg/L,明显高于健康对照组的(2.12±0.62)mg/L和(4.89±1.27)mg/L,其差异均有统计学意义(t=57.937,t=5.634;P<0.05)。观察组患者治疗后HIF-1α、IL-8和LTB4指标分别为(0.76±0.22)ng/ml、(36.88±4.26)pg/ml和(368.26±57.29)pg/ml,均显著低于治疗前的(1.04±0.27)ng/ml、(53.21±6.22)pg/ml和(553.25±62.03)pg/ml,其差异均有统计学意义(t=7.100,t=19.130,t=19.349;P<0.05)。结论:CG和HIF-1α检测在COPD患者病情评估中具有重要参考价值,可为评估患者病情及诊疗方案提供依据。Objective To study the evaluation value of cholyglycine （CG） and hypoxia inducible factor 1 alpha （HIF-1α） in detecting patients with chronic obstructive pulmonary disease （COPD） at acute attack stage. Methods： 78 patients with COPD at acute attack stage were divided into observation group, and 78 healthy persons who were confirmed by physical examination at the same time were divided into control group. The expressions of CG and HIF-1α of the two groups were compared, and the effect and clinical value of CRP, IL-8 and LTB4 of patients in the diagnosis were evaluated. Results： In prior treatment, the concentrations of CG （11.45±1.28 mg/L） and CRP （28.68±3.63 mg/L）of observation group were significantly higher than that （2.12±0.62 mg/L, 4.89±1.27 mg/L）of control group （t=57.937, t=5.634, P〈0.05）, respectively. And for observation group, HIF-1α（0.76±0.22 ng/mL）, IL-8（36.88±4.26 pg/mL） and LTB4 （368.26±57.29 pg/mL） of post-treatment were significantly lower than that （1.04±0.27ng/mL, 53.21±6.22pg/mL, 553.25±62.03 pg/mL） of pretreatment （t=7.100, t=19.130, t=19.349, P〈0.05）, respectively. Conclusion： The detections of CG and HIF-1 in the evaluation of patients with COPD has important clinical reference value, and they can provide basis for the assessment of state of illness, and the relevant diagnosis and treatment scheme.

关 键 词：血清甘胆酸 缺氧诱导因子1Α 慢性阻塞性肺疾病 

分 类 号：R563[医药卫生—呼吸系统]