泄浊化瘀饮联合氯沙坦治疗早中期慢性肾衰竭疗效及对CTGF、BMP-7的影响  

Clinical Effects Investigation of Xiezhuo Huayu Decoction Combined with Losartan in Treatment of Chronic Renal Failure for Early and Middle Stage and Influence on CTGF and BMP-7

作　　者：朱斐斐[1] 姚金[1] 刘波[1] 刘福和[2] 

机构地区：[1]湖州市中心医院药剂科,浙江湖州313000 [2]浙江医药高等专科学校药学院,浙江宁波315100

出　　处：《中华中医药学刊》2018年第1期229-231,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省教育厅科研项目(Y201534611)

摘　　要：目的：探讨泄浊化瘀饮联合氯沙坦治疗早中期慢性肾衰竭疗效及对CTGF、BMP-7的影响。方法：120例早中期慢性肾衰竭患者,以随机数字表法分为对照组（60例）和观察组（60例）,分别给予氯沙坦单用和在此基础上加用泄浊化瘀饮辅助治疗;比较两组患者近期疗效,治疗前后中医证候积分、24 h尿蛋白定量、尿素氮、肌酐、e GFR、CTGF及BMP-7水平等。结果：观察组患者近期疗效显著优于对照组（P〈0.05）;观察组患者治疗后中医证候积分均显著低于对照组、治疗前（P〈0.05）;观察组患者治疗后肾脏功能指标水平均显著优于对照组、治疗前（P〈0.05）;观察组患者治疗后CTGF和BMP-7水平均显著优于对照组、治疗前（P〈0.05）。结论：泄浊化瘀饮联合氯沙坦治疗早中期慢性肾衰竭可有效改善临床症状体征,提高肾脏功能,并有助于调节CTGF和BMP-7水平。Objective： To investigate the clinical effects of Xiezhuo Huayu Decoction combined with losartan in the treatment of chronic renal failure for early and middle stage and influence on CTGF and BMP-7. Methods：A total of 120 patients with chronic renal failure for early and middle stage were chosen and randomly divided into control group（60 patients） with losartan used alone and observation group（60 patients） with Xiezhuo Huayu Decoction on the basis of control groupand the clinical efficacy for short-term,the TCM syndrome scores,24 h urinary protein amount,the levels of urea nitrogen,creatinine,e GFR,CTGF and BMP-7 of both groups were compared. Results： The clinical efficacy for short-term of observation group was significantly better than that of the control group（ P 〈 0. 05）. The TCM syndrome scores of observation group after treatment were significantly lower than those of control group and before treatment（ P 〈0. 05）. The levels of renal function index of observation group after treatment was significantly better than those of the control group and before treatment（ P 〈 0. 05）. The levels of CTGF and BMP-7 of observation group after treatment were significantly better than those of the control group and before treatment（ P 〈 0. 05）. Conclusion： Xiezhuo Huayu Decoction combined with losartan in the treatment of chronic renal failure for early and middle stage can efficiently improve the clinical symptoms and signs,higher the renal function and be helpful to regulate the levels of CTGF and BMP-7.

关 键 词：中药 氯沙坦 慢性肾衰竭 疗效 CTGF BMP-7 

分 类 号：R692.5[医药卫生—泌尿科学]