乌灵胶囊联合奥氮平对精神分裂症患者睡眠质量的影响  

Effect of Wuling Capsule Combined with Olanzapine on Sleep Quality of Patients with Schizophrenia

作　　者：王轶虎[1] 崔力军[1] 潘鑫[1] 陶百平[1] 

机构地区：[1]湖州市第三人民医院

出　　处：《中华中医药学刊》2018年第1期245-247,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：湖州市科学技术局公益性技术应用研究(一般)项目(2014GYB31)

摘　　要：目的：探讨给予精神分裂症患者乌灵胶囊联合奥氮平治疗对睡眠质量的影响。方法：90例精神分裂症患者,采用数字抽样法将所有患者分为两组,各45例。对照组给予奥氮平治疗,观察组给予乌灵胶囊联合奥氮平治疗。对比分析两组治疗效果、PSQI评分、PANSS评分、TESS评分。结果：治疗后两组PSQI各因子评分及总分均明显低于治疗前,差异有统计学意义（P〈0.05）。治疗后对照组的入睡时间得分比观察组明显下降,差异有统计学意义（P〈0.05）。治疗后观察组的日间功能障碍得分比对照组明显下降,差异有统计学意义（P〈0.05）。治疗后两组PANSS各因子分及总分均比治疗前明显下降,差异有统计学意义（P〈0.05）。治疗后观察组的精神病理因子明显优于对照组（P〈0.05）,而对照组阳性因子明显优于观察组,差异有统计学意义（P〈0.05）。对照组TESS评分均明显高于观察组,差异有统计学意义（P〈0.05）。两组治疗效果对比,无明显差异（P〉0.05）。结论：给予精神分裂症睡眠障碍患者乌灵胶囊联合奥氮平治疗效果显著,可明显改善患者睡眠状态,促进预后,利于其早日回归家庭及社会,且药物安全性较高。Objective： To explore the effects of Wuling Capsule combined with Olanzapine on sleep quality of patients with schizophrenia. Methods： Ninety schizophrenia patients with mental disorders were selected and all patients were divided into two groups by digital sampling,with 45 cases in each group. The control group was given Olanzapine for treatment,whereas the observation group was treated with Wuling Capsule combined with Olanzapine. The treatment effect and scores of PSQI,PANSS and TESS in the two groups were analyzed and compared. Results： After treatment,scores of all the indexes of PSQI and total score in the two groups were significantly reduced than those before treatment,and the difference was statistically significant（ P 〈 0. 05）. After treatment,time for patients to fall into sleep was significantly reduced in both groups,and the reduction in the control group was more significant than that in the observation group,and the difference was statistically significant（ P 〈 0. 05）. After treatment,the score of daytime dysfunction in the observation group was ignificantly lowered than that in the control group,and the difference was statistically significant（ P〈 0. 05）. After treatment,scores of all the indexes of PSQI and total score in the two groups were significantly reduced than those before treatment,and the difference was statistically significant（ P 〈 0. 05）. After treatment,psychopathological factors in the observation group were significantly better than those of the control group（ P 〈 0. 05）,and the positive factors in the control group were significantly better than those in the observation group,and the differences were statistically significant（ P 〈 0. 05）. The score of TESS indexes in the observation group was higher than those in the control group and the difference was statistically significant（ P 〈 0. 05）. However,there was no statistically significant difference in therapeutic effect between the two groups（ P 〉 0. 05）. Conclusion： For sch

关 键 词：乌灵胶囊 奥氮平 精神分裂症 睡眠质量 安全性 

分 类 号：R285.5[医药卫生—中药学]