COPD患者血清中IL-21的表达及其与肺功能、生活质量的相关性分析  

Expression of IL-21 in serum of COPD patients and its correlation with lung function and quality of life

作　　者：吴莹莹 江成养 郭卫东 龚志均 谭康新 

机构地区：[1]南方医科大学南海医院,528000

出　　处：《中国实用医药》2018年第1期1-3,共3页China Practical Medicine

基　　金：2016年佛山市卫生和计划生育局医学科研课题(项目编号:20160175)

摘　　要：目的探讨慢性阻塞性肺疾病(COPD)患者血清中白细胞介素-21(IL-21)表达水平及其与肺功能、生活质量的相关性。方法 30例COPD急性加重期患者作为急性加重期COPD组,30例COPD稳定期患者作为稳定期COPD组,30例健康体检者作为对照组,采用Th1/Th2/Th17定量抗体芯片检测各组IL-21水平,采用意大利科时迈肺功能仪检查各组肺功能,采用COPD评估测试量表(CAT)评定各组生活质量,并分析IL-21水平与肺功能、生活质量的相关性。结果急性加重期COPD组IL-21水平、CAT评分均高于稳定期COPD组和对照组,一秒钟用力呼气容积占预计值百分比(FEV1%)、一秒钟用力呼气容积占用力肺活量百分比(FEV1/FVC)均低于稳定期COPD组和对照组,差异均具有统计学意义(P<0.05);稳定期COPD组IL-21水平、CAT评分均高于对照组,FEV1%、FEV1/FVC均低于对照组,差异均具有统计学意义(P<0.05)。相关性分析显示,稳定期COPD患者血清IL-21水平与一秒钟用力呼气容积(FEV1)、FEV1/FVC、用力肺活量(FVC)呈负相关(r=-0.315、-0.198、-0.593,P<0.05),稳定期COPD患者血清IL-21水平与CAT评分呈正相关(r=0.382,P<0.05);急性加重期COPD患者血清IL-21水平与FEV1、FEV1/FVC、FVC呈负相关(r=-0.693、-0.485、-0.149,P<0.05),急性加重期COPD患者血清IL-21水平与CAT评分呈正相关(r=0.682,P<0.05)。结论 COPD患者血清中IL-21呈高表达,且与肺功能、生活质量存在紧密联系。Objective To discuss the expression of interleukin-21（IL-21） in serum of chronic obstructive pulmonary disease（COPD） patients and its correlation with lung function and quality of life. Methods There were 30 patients with acute exacerbation of COPD as acute exacerbation COPD group, 30 stable COPD patients as stable COPD group, and 30 physical examination people as control group. Th1/Th2/Th17 quantitative antibody chip was used to detect IL-21 levels in each group. Lung function in each group was examined by Italy Keshimai lung function instrument. COPD assessment test（CAT） was used to assess the quality of life in each group, and the correlation between IL-21 level and lung function and quality of life was analyzed. Results Acute exacerbation COPD group had higher IL-21 level and CAT score than stable COPD group and control group, and lower forced expiratory volume in 1 second percentage of expected value（FEV1%） and forced expiratory volume in 1 second percentage of forced vital capacity（FEV1/FVC） than stable COPD group and control group. Their difference was statistically significant（P〈0.05）. Stable COPD group had higher IL-21 level and CAT score than control group, and lower FEV1% and FEV1/FVC than the control group. Their difference was statistically significant（P〈0.05）. The correlation analysis showed that the level of serum IL-21 was negatively correlated with forced expiratory volume in 1 second（FEV1）, FEV1/FVC, and forced vital capacity（FVC） in patients with stable COPD（r=-0.315,-0.198,-0.593, P〈0.05）, and the level of serum IL-21 was positively correlated with the CAT score in patients with stable COPD（r=0.382, P〈0.05）. The level of serum IL-21 in patients with acute exacerbation of COPD was negatively correlated with FEV1, FEV1/FVC and FVC（r=-0.693,-0.485,-0.149, P〈0.05）, and the level of serum IL-21 was positively correlated with the CAT score in patients with acute exacerbation of COPD（r=0.682, P〈0.05）. Conclusion The level of IL-21 in ser

关 键 词：慢性阻塞性肺疾病 白细胞介素-21 肺功能 生活质量 相关性 

分 类 号：R563.9[医药卫生—呼吸系统]