对羟基苯乙酰胺合成新工艺  

New Synthetic Process of p-Hydroxyphenylacetamide

作　　者：何晓强[1] 李安梅[1] 

机构地区：[1]荆楚理工学院化工与药学院,湖北荆门448000

出　　处：《化学与生物工程》2018年第1期29-30,共2页Chemistry & Bioengineering

基　　金：荆楚理工学院项目(ZR201409)

摘　　要：以对氯苯乙腈为起始原料,经羟腈水解、亲核取代和浓氨水酰胺化等3步反应合成对羟基苯乙酰胺。确定适宜的酰胺化反应条件为:以硼络合物为催化剂、浓氨水和对羟基苯乙酸物质的量比4∶1、反应温度20℃、反应时间6h,在该条件下,酰胺化反应收率为78%,总收率为66.7%(以对氯苯乙腈计)。Using p-chlorobenzyl cyanide as a starting material, we synthesized p-hydroxyphenylacetamide through the three-step reaction of hydrolysis of hydroxyl nitrile, nucleophile substitution, and amidation by concentrated ammonia water. The optimum conditions of amidation reaction were determined as follows： boron complex as a catalyst,the molar ratio of concentrated ammonia water to p-hydroxyphenylacetic acid of 4 ： 1 ,the reaction temperature of 20 ℃ ,and the reaction time of 6 h. Under above conditions,the yield of amidation reaction was 78% ,and the total yield was 66.7%（on the basis of p-chlorobenzyl cyanide）.

关 键 词：阿替洛尔 对羟基苯乙酰胺 合成工艺 

分 类 号：TQ246.31[化学工程—有机化工]