默克尔细胞在皮肤触觉形成中的作用研究进展  

Advances in the research of function of Merkel cells in tactile formation of skin

作　　者：游兴[1] 魏在荣[1] 

机构地区：[1]贵州遵义医学院附属医院整形外科,563000

出　　处：《中华烧伤杂志》2018年第1期51-54,共4页Chinese Journal of Burns

基　　金：国家自然科学基金（81360295、81560315）

摘　　要：皮肤是人体最大的器官，但在日常生活中极易受损。皮肤软组织缺损，尤其是在指腹、嘴唇等无毛区的皮肤软组织缺损，修复后触觉功能的减退或缺失导致患者失去感知物体空间属性的能力，严重影响着患者生活质量，因此触觉的增敏甚至重获对患者来说意义重大。Skin is the largest sense organ of human, with many mechanoreeeptor cells under epidermis or dermis of skin and Merkel cell is one of them. It has been confirmed that Merkel cells play an important role in the process of mechanical transmission of mammalian soft tactile stimulation. Researches showed that Merkel cells had close relation to tactile formation and functioned by Merkel cell-neurite complexes and ion channels Piezo2. This article reviews Merkel cells and the function, problem and prospect of Merkel cells in tactile formation.

关 键 词：默克尔细胞 触觉 离子通道 默克尔细胞-神经突复合体 

分 类 号：R339.11[医药卫生—人体生理学]