黄芪甲苷治疗糖尿病及其并发症药理作用研究进展  

Research advances on astragaloside-IV in treatment of diabetes mellitus and its complications pharmacological effects

作　　者：尤良震[1] 林逸轩 方朝晖[2] 申国明[1] 赵进东[2] 汪婷婷[1] 

机构地区：[1]安徽中医药大学,安徽合肥230038 [2]安徽中医药大学第一附属医院,安徽合肥230038

出　　处：《中国中药杂志》2017年第24期4700-4706,共7页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81573944;81273646);国家中医药管理局中医临床基地科研专项(JDZX2012001);国家中医药管理局中医药重点学科(20091221);国家中医药管理局国家基本公共卫生服务项目(20131012)

摘　　要：糖尿病已经成为严重威胁人类健康的全球性公共卫生问题。中医药以其"多靶点"的作用特点在糖尿病及其并发症的防治上独具优势。黄芪甲苷是中药黄芪的主要活性成之一,具有改善内皮细胞与新生血管功能、抗炎、抗氧化、调节能量代谢、神经保护、抗癌等作用。该文对黄芪甲苷防治糖尿病及其并发症进行综述,显示出黄芪甲苷具有降血糖、降血脂、改善胰岛素抵抗、抑制炎症反应与氧化应激等作用,能够改善糖尿病动物与细胞模型中糖尿病血管病变、糖尿病肾病、糖尿病视网膜病变、糖尿病周围神经病变、糖尿病心肌病等病理性损伤。黄芪甲苷可能是一种潜在治疗糖尿病及其并发症的中药活性物质。Diabetes has become a global public health problem that seriously threatens human health. Traditional Chinese medicine, the characteristics of the role of multiple targets, has a unique advantage in the prevention and treatment of diabetes mellitus and its complications. Astragaloside-Ⅳ （AS-Ⅳ）, one of the main activities of Astragalus membranaceus, has a series of pharmacological effects including improvement in the function of endothelial cells and neovascularization, anti-inflammatory, antioxidant, regulating energy metabolism, protectionnervous, anti-cancer and so on. In this paper, AS-Ⅳ to prevent and treat diabetes and its complications has been reviewed, which has effect on lowering blood sugar, lowering blood pressure, improving insulin resistance, inhibiting inflammatory reaction and oxidative stress. Additionally, it also can improve the diabetic animal and cell model of diabetic vascular disease, diabetic nephropathy, diabetic retinopathy, diabetic peripheral neuropathy, diabetic cardiomyopathy and other pathological damages. AS-Ⅳ may be a potential active substance for the treatment of diabetes and its complications.

关 键 词：黄芪甲苷 糖尿病 药理作用 新药 

分 类 号：R285[医药卫生—中药学]