臭牡丹的化学成分研究  

Studies on chemical constituents of Clerodendrum bungei

作　　者：张贵杰[1] 代禄梅 张斌 张永丽 王恒山 梁东 

机构地区：[1]桂林医学院药学院,广西桂林541004 [2]广西师范大学化学与药学学院省部共建药用资源化学与药物分子工程国家重点实验室,广西桂林541004

出　　处：《中国中药杂志》2017年第24期4788-4793,共6页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(21562017);广西自然科学基金项目(2014GXNSFBA118189)

摘　　要：研究臭牡丹Clerodendrum bungei的化学成分。采用硅胶,Sephadex LH-20,MCI,ODS和半制备HPLC等色谱技术,从臭牡丹95%乙醇提取物中分离得到10个化合物,分别鉴定为11,12,16S-trihydroxy-7-oxo-17(15→16),18(4→3)-diabeo-abieta-3,8,11,13-tetraen-18-oic acid(1),12 S*,13R*-dihydroxy-9-oxo-octadeca-10(E)-enoic acid(2),赪桐苷A(3),trichotomoside(4),山橘脂酸(5),4'-O-methylscutellarein(6),neroplomacrol(7),butylitaconic acid(8),hexylitaconic acid(9),对羟基苯甲酸(10)。化合物1和2为新天然产物,化合物7~10为首次从该属植物中分离得到,化合物为3,5,6首次从该植物中分离得到。Ten compounds were isolated from the 95% aqueous EtOH extract of Clerodendrum bungei by a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, MCI, ODS, and semi-preparative HPLC. Their structures were elucidated as 11,12,16S-trihydroxy-7-oxo-17（15→16）,18（4→3）-diabeo-abieta-3,8,11,13-tetraen-18-oic acid （1）, 12S＊,13R＊-dihydroxy-9-oxo-octadeca-10（E）-enoic acid （2）, clerodenoside A （3）, trichotomoside （4）, glycosmisic acid （5）, 4＇-O-methylscutellarein （6）, neroplomacrol （7）, butylitaconic acid （8）, hexylitaconic acid （9）, p-hydroxybenzonic acid （10） by their physicochemical properties and spectroscopic data. Compounds 1 and 2 are new natural products, while compounds 7-10 were obtained from the genus Clerodendrum for the first time, and compounds 3, 5, 6 were isolated from this plant for the first time.

关 键 词：臭牡丹 马鞭草科 化学成分 二萜 

分 类 号：R284.1[医药卫生—中药学]