沙咪珠利预防鸡球虫病的药效试验研究  

Study on the Efficacy of Acetamizuril against Coccidiosis in Chickens

作　　者：佘如凤 费陈忠[1] 赵其平[1] 薛飞群[1] 张丽芳 张可煜[1] 王米[1] 王霄旸[1] 王春梅 刘迎春[1] 郑文丽 

机构地区：[1]中国农业科学院上海兽医研究所农业部动物寄生虫学重点开放实验室中国农业科学院兽药安全评价与兽药残留研究重点开放实验室,上海闵行200241

出　　处：《中国兽医杂志》2017年第11期88-92,共5页Chinese Journal of Veterinary Medicine

基　　金：国家重点研发计划专项(2016YFD0501303);农业部公益性行业专项(201303038-9)

摘　　要：为了解一种新型三嗪类抗球虫化合物沙咪珠利在临床预防鸡球虫病的合理使用剂量和对鸡球虫病常见4种病原的有效性和敏感性,采用抗鸡球虫笼养试验模型和抗球虫活性指数、盲肠病变计分、相对卵囊产量、增重等指标评价沙咪珠利的药效。结果显示,沙咪珠利饲料中添加9 mg/kg以上时,对柔嫩艾美耳球虫的抗球虫活性稳定在高效水平,以10 mg/kg作为临床使用推荐剂量是相对安全和合理的。沙咪珠利饲料中添加10 mg/kg,预防鸡柔嫩艾美耳球虫(Eimeria tenella),毒害艾美耳球虫(Eimeria necatrix)、堆型艾美耳球虫(Eimeria acervulina)和巨型艾美耳球虫(Eimeria maxima)引起的球虫病的抗球虫指数分别为197、188、194和190,抗球虫活性达高效水平,沙咪珠利具有预防4种常见致病虫株引发的球虫病的疗效,其作用机理等有待进一步的研究。Anticoccidial battery tests＊ model was adopted to evaluate the efficacy and proper dose of a new triazine compound Acetamizuril against coccidiosis in chickens. The assessment was performed regarding anticoccodial index （ACI）, lesion scores （LS）, relative oocyst production（ ROPG）, and weight gain（WG）. Excellent anticoccidal activity of Acetamizuril was observed at dose of 9mg/kg and above. A dose of 10 mg/kg was recommended to clinical dose for its safety and effectiveness. ACIs of Acetamizuril- treated groups were 197,188, t94 and 190 for Eimeria tenella, Eimeria necatrix, Eimeria acervulina and Eimeria maxima, respectively, indicating that Acetamizuril was added to the diet at doses of 10 mg/kg can prevent coccidiosis caused by 4 kinds of Eimeria coccidium. Further studies are needed to explore the mechanism of action of Acetamizuril.

关 键 词：沙咪珠利 鸡球虫病 药效 

分 类 号：S859.795[农业科学—临床兽医学]