Drug-polymer inclusion complex as a new pharmaceutical solid form  

作　　者：Xiaotong Yang Zhi Zhong Jun Xu Yanbin Huang 

机构地区：[1]Key Laboratory of Advanced Materials (MOE), Department of Chemical Engineering, Tsinghua University, Beijing 100084, China

出　　处：《Chinese Chemical Letters》2017年第11期2099-2104,共6页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (No. 21434008)

摘　　要：The solid forms of drugs play a central role in controlling their physicochemical properties and consequently the bioavailability. Multiple types of drug solid forms have been developed to achieve the desirable pharmaceutical profiles, but new solid forms will provide more options for the solid-state property optimization and hence are highly desirable. This review focuses on a new pharmaceutical solid form, drug-polymer inclusion complexes （ICs）, and summarizes their structural features, structure- property relationships, as well as potential pharmaceutical applicationsThe solid forms of drugs play a central role in controlling their physicochemical properties and consequently the bioavailability. Multiple types of drug solid forms have been developed to achieve the desirable pharmaceutical profiles, but new solid forms will provide more options for the solid-state property optimization and hence are highly desirable. This review focuses on a new pharmaceutical solid form, drug-polymer inclusion complexes （ICs）, and summarizes their structural features, structure- property relationships, as well as potential pharmaceutical applications

关 键 词：Pharmaceutical solid forms Crystalline inclusion complex Thermal stability Dissolution profiles Homopolymers Block copolymers 

分 类 号：TQ460.1[化学工程—制药化工]