An amino acid-based gelator for injectable and multi-responsive hydrogel  

作　　者：Wei Xiong Hantao Zhou Chong Zhang Hua Lu 

机构地区：[1]Beijing National Laboratory for Molecular Sciences, Center for Soft Matter Science and Engineering Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

出　　处：《Chinese Chemical Letters》2017年第11期2125-2128,共4页中国化学快报（英文版）

基　　金：supported by [18_TD$IF]State High-Tech Development Program of China (863 Program, No. 2015AA020941);the National Natural Science Foundation of China(Nos. NSFC21474004 and NSFC21434008);the Youth Thousand-Talents Program of China for support

摘　　要：Hydrogels formed by gelators have attracted growing attention for their promising application in biomaterials and biotechnology, We describe in this paper the generation and characterization of a novel photo-, thermal- and pH-responsive hydrogel based on an amino acid gelator AA-Azo-EG6. Specifically, the gelator bears an amino acid head, an azobenzene （Azo） linker, and a short oligoethylene glycol tail （EG6）. The resulting AA-Azo-EG6 hydrogel is injectable and exhibits interesting helical self-assembled structures, Meanwhile, the hydrogel is able to experience a gel-sol or gel-precipitate phase transition responding to external stimuli. Thus, this AA-Azo-EG6 gelator is a promising building block for intelligent materials and drug delivery.Hydrogels formed by gelators have attracted growing attention for their promising application in biomaterials and biotechnology, We describe in this paper the generation and characterization of a novel photo-, thermal- and pH-responsive hydrogel based on an amino acid gelator AA-Azo-EG6. Specifically, the gelator bears an amino acid head, an azobenzene （Azo） linker, and a short oligoethylene glycol tail （EG6）. The resulting AA-Azo-EG6 hydrogel is injectable and exhibits interesting helical self-assembled structures, Meanwhile, the hydrogel is able to experience a gel-sol or gel-precipitate phase transition responding to external stimuli. Thus, this AA-Azo-EG6 gelator is a promising building block for intelligent materials and drug delivery.

关 键 词：Multi-responsive Injectable Amino acid Gelator Hydrogel 

分 类 号：TQ427.26[化学工程]