降氟改水前后儿童血清氟含量与智商相关关系调查  

The correlation between the level of serum fluoride and intelligence quotient among children before and after defluoridation

作　　者：王广吉[1] 张明访 汪秋实 韩翱瀚 高明献[1] 林萍[4] 向全永[4] 

机构地区：[1]江苏省泗洪县人民医院,223900 [2]江苏省泗洪县疾病预防控制中心 [3]东南大学公共卫生学院 [4]江苏省疾病预防控制中心

出　　处：《首都公共卫生》2017年第6期274-277,共4页Capital Journal of Public Health

基　　金：国家自然科学基金项目(编号:81273015)

摘　　要：目的探讨降氟改水措施对儿童血清氟含量及智商的影响,为降氟改水效果评估及地氟病防治提供依据。方法采用氟离子电极法测定饮水和血清中的氟含量,用联合型瑞文智商测定中国农村修订版测定儿童智商。结果儿童血清氟含量由改水前的(0.081±0.019 mg)/L下降至改水后的(0.040±0.005 mg)/L,改水前后差异有统计学意义(t=20.15,P<0.001);儿童智商由改水前的92.71±13.27上升到改水后的110.49±15.12,改水前后差异有统计学意义(t=-10.29,P<0.001)。改水前儿童智商与血清氟间有显著的剂量-效应关系。结论血清氟含量是评价地方性氟中毒的重要指标,血清氟含量的增加可以引起儿童智力发育损伤,降氟改水是饮水型地方性氟中毒的重要措施。Objective To study the effect of defluoridation on the level of serum fluoride and children＇s intelligence quotient（ IQ）,so as to provide evidences for the effective assessment of defluoridation projects and the prevention of endemic fluorosis. Methods The fluoride in serum and drinking water were tested with fluoride ion selective electrode method. The children‘s IQ were tested with Combined Raven＇s Test for Rural China. Results The level of fluoride in serum among children after defluoridation（ 0. 040 ± 0. 005 mg/L） was significant lower than that before defluoridation（ 0. 081 ± 0. 019 mg/L）. The difference was statistically significant（ t = 20. 15,P 0. 001）. The children ＇s IQ after defluoridation（ 92. 71 ± 13. 27） was significant higher than that before defluoridation（ 110. 49 ± 15. 12）. The difference was statistically significant（ t =-10. 29,P 0. 001）. The serum fluoride had a significant dose-response relationship with the children ＇s IQ before defluoridation.Conclusion Serum fluoride level was an important index for endemic fluorosis evaluation. Increment of serum fluoride may damage children ＇s intelligence. Defluoridation was an important measure for the prevention of endemic fluorosis caused by fluoride in drinking water.

关 键 词：血氟 智商 效果评估 

分 类 号：R599.1[医药卫生—内科学]