相变材料运血箱海上血液前送补给性能评价研究  

Effect of blood containers containing phase-changed material on quality of stored RBCs on the sea

作　　者：阎少多[1] 朱正洪 刘敏霞 贺玉莹 张玉华[1] 王捷熙[1] 易晓阳[1] 贾向志[1] 韩颖[1] 王东根[1] 

机构地区：[1]军事医学科学院野战输血研究所,全军血液安全与保障重点实验室,血液安全保障技术研究北京市重点实验室,北京100850 [2]解放军422医院输血科,广东湛江524005

出　　处：《军事医学》2017年第9期707-710,共4页Military Medical Sciences

摘　　要：目的开展相变材料运血箱海上血液前送补给实地评估,对携行的悬浮红细胞质量进行评价研究,为海上血液冷链储运系统的完善提供参考。方法模拟海上血液前送补给实际情况,依托海军某综合补给任务,开展相变材料运血箱保存悬浮红细胞陆地前送(100 min)、海上前送(45 h)及前送补给悬浮红细胞继续在舰船上储运(7 d)等的检验评估,并就悬浮红细胞储运过程中游离血红蛋白含量、血液生化指标等进行检测。结果在血液前送阶段,相变材料运血箱内温度由4.1℃上升至9.5℃,游离血红蛋白、血钾、乳酸脱氢酶含量分别升高至(0.083±0.032)g/L、(15.097±1.791)mmol/L和(106.00±17.83)U/L;在血液储存阶段,海上保存悬浮红细胞的游离血红蛋白、血钾、乳酸脱氢酶含量分别升高至(0.111±0.035)g/L、(27.238±3.509)mmol/L和(227.00±111.94)U/L,血钠含量降低至(113.63±4.012)mmol/L。结论相变材料运血箱可在较复杂环境条件下(多种运输途径、持续温度变化、携行及舰船振荡),保持箱内血液在较长时间(45 h)维持在恒定温度范围(4~10℃),并保证前送血液质量。此外,在海上储存多天的悬浮红细胞游离血红蛋白含量更高,储存损伤较陆地常规保存更大。Objective To provide reference for the cold chain of stored RBCs on the sea by evaluating both blood containers containing phase-changed materials and the quality of stored RBCs during transportation.Methods In order to simulate blood supply on the sea,we transported the stored RBCs on land（100 min）,on the sea（45 h） and stored them on the sea for another 7 days.The free hemoglobin（Hb）,lactate dehydrogenase（LDH）,and concentrations of K＋and Na＋were measured.Results The temperature of the blood container containing phase-changed materials rose from 4.1℃to 9.5℃.The contents of free Hb,K＋and LDH were increased to（0.083 ± 0.032） g/L,（15.097 ± 1.791） mmol/L,and（106.00 ± 17.83） U/L,respectively.During blood storage,the contents of the above three indices were increased to（0.111 ± 0.035） g/L,（27.238 ± 3.509） mmol/L and（227.00 ± 111.94） U/L,while Na＋decreased to（113.63 ±4.012） mmol/L.Conclusion The temperature of the blood container containing phase-changed materials can be maintained at a constant temperature under more complicated environmental conditions,and the quality of the stored RBCs can be ensured.RBCs stored on the sea for more than 7 days are damaged more seriously than those stored on land.

关 键 词：相变材料 悬浮红细胞 海上 前送补给 质量评价 

分 类 号：R82[医药卫生—临床医学]