同种异体富血小板胶治疗慢性难愈合溃疡的有效性研究  

Efficacy analysis of allogeneic rich-platelet geltreatment for refractory skin ulcer

作　　者：刁荣华[1] 王泽蓉[1] 宋娜丽[1] 黄红梅[1] 范娅涵[1] 

机构地区：[1]第三军医大学西南医院输血科,重庆400038

出　　处：《中国输血杂志》2017年第11期1268-1270,共3页Chinese Journal of Blood Transfusion

基　　金：护理科技创新基金(SWHLKJ-A07)

摘　　要：目的观察同种异体富血小板胶治疗慢性难愈合溃疡的临床有效性。方法 6名慢性难愈性皮肤溃疡的患者行同种异体富血小板胶(APG)治疗,采集与患者同血型健康献血者的血液,制备富含血小板血浆(PRP),将PRP与凝血酶粉-钙剂按(10∶1)混合制备成APG。采用常规清创处理后将同型APG敷于溃疡处,3-4 d换药1次。结果 APG处理伤口后无明显炎症反应,经过平均34 d,5-8次治疗,患者难愈合溃疡创面面积缩小(98.1±1)%,治疗前创面平均面积为(43.10±60.07)cm2,治疗后平均面积为(0.17±0.07)cm2,均基本愈合。结论同种异体富血小板胶治疗难愈性溃疡愈合效果显著,无不良反应,值得推广应用。Objective This study focuses onevaluating the efficacy of allogeneic rich platelet gel（ APG） application in the treatment of chronic refractory skin ulcer. Methods 6 patients with chronic refractory skin ulcer were treated with allogeneic rich platelet gel. APG from healthy donors was produced by mixing platelet rich plasma（ PRP） and thrombin-calcium ata10 to1 ratio. The woundedskinwas treated with APG as a coverdressing after traditional treatment. The APGlayerwas renewed every 3-4 days. Results The APG treatmentontheface skinof the ulcer can speed up the healing of wound with no adverse effectwhilethe ulcer area was reduced significantly from 43. 10±60. 07 cm^2 to 0. 17±0. 07 cm^2. After 10 cycles of APG treatment,the ulcer size hadshrunken by 98. 1% ±1%,which is considered acceptablerecovery. Conclusion The application of APG in the treatment of chronic refractory skin ulcer is safe and effective.

关 键 词：同种异体富血小板胶 难愈性溃疡 

分 类 号：R193.3[医药卫生—卫生事业管理] R457.11[医药卫生—公共卫生与预防医学]