鸸鹋油微乳处方优化及稳定性研究  

Study on optimization and stability of Emu Oil microemulsion prescription

作　　者：兰小群[1] 沈晓 袁娴[1] 王利胜[2] 

机构地区：[1]广东岭南职业技术学院,广东广州510663 [2]广州中医药大学中药学院,广东广州510006

出　　处：《中国医药导报》2018年第1期38-41,共4页China Medical Herald

基　　金：广东岭南职业技术学院科研项目(KB201402)

摘　　要：目的制备鸸鹋油微乳,并对制剂稳定性进行考察。方法采用加水法制备鸸鹋油微乳,并用单因素法和正交试验优化处方工艺。以外观形状评分、离心稳定常数、粒径为指标,通过筛选鸸鹋油用量、Tween80/Span80的比例、甘油用量制备鸸鹋油微乳,并考察最优处方工艺所制得的制剂的稳定性。结果优化的处方为:鸸鹋油0.03 g,Tween80/Span80(4∶1)0.80 g,甘油0.20 g,加去离子水至20 mL,所制备的微乳为O/W型,澄清透明,平均粒径为100~200 nm,离心后未见分层和油滴。结论正交试验设计能够客观地优化鸸鹋油微乳处方,所制备的样品性质稳定。Objective To prepare the Emu oil Microemulsion and investigate the stability of the preparation. Methods The Emu oil Microemulsion was prepared by adding water and the prescription process was optimized by single factor method and orthogonal test. The appearance shape score, the centrifugal stability constant and the particle size were selected as the index, the Emu oil Mieroemulsion was prepared by screening the ratio of Tween 80/Span80 and the amount of glycerol and the stability of the preparation prepared by the optimal formulation was investigated. Results The optimal Microemulsion was composed of emu oil 0.03 g, Tween80/Span80 （4：1） 0.80 g, glycerol 0.20 g and plused deionized water to 20 mL. The prepared Mieroemulsion was O/W type, which was clear and transparent, the average particle size of 100-200 nm and there is no separation after the separation and oil droplets. Conclusion The Emu oil Microemulsion made by this optimum formulation and preparation procedure has excellent physicochemieal properties.

关 键 词：鸸鹋油 微乳 处方 稳定性 

分 类 号：R285.5[医药卫生—中药学]