加味黄芪赤风汤治疗IgA肾病蛋白尿的单病例随机对照研究  

Single case randomized controlled research of Modified Huangqi Chifeng Decoction in the treatment of proteinuria due to IgA nephropathy

作　　者：焦志娜[1] 赵明明[1] 张昱[1] 李刘生[1] 司远 

机构地区：[1]中国中医科学院西苑医院肾病科,北京100091

出　　处：《中国医药导报》2018年第1期95-98,共4页China Medical Herald

基　　金：中国中医科学院基本科研业务费自主选题项目(ZZ0708105)

摘　　要：目的观察加味黄芪赤风汤治疗IgA肾病蛋白尿的有效性及安全性。方法病例来源于2011年12月~2012年12月就诊于中国中医科学院西苑医院肾病科门诊患者,纳入5例轻到中度蛋白尿、肾功能正常且属中医气虚血瘀证型的IgA肾病患者,采用单病例随机对照设计,治疗期应用加味黄芪赤风汤联合替米沙坦,对照期应用替米沙坦,疗效指标为24 h尿蛋白定量与中医症状积分,安全性指标为肝肾功能以及血常规。结果每例患者治疗期中医症状积分均较对照期有不同程度的减少(P<0.05);将5例患者中医症状积分合并,治疗期较对照期明显改善(P<0.05)。每例患者治疗期24 h尿蛋白定量均较对照期减少(P<0.05);将5例患者24 h尿蛋白定量合并,治疗期较对照期明显减少(P<0.05)。结论加味黄芪赤风汤治疗IgA肾病蛋白尿安全且有效,单病例随机对照设计应用于中医临床研究具有可行性。Objective To observe the efficacy and safety of Modified Huangqi Chifeng Decoction in the treatment of proteinuria due to IgA nephropathy. Methods The cases came from the Outpatient Department of Nephrology in Xiyuan Hospital, China Academy of Chinese Medical Sciences from December 2011 to December 2012. 5 cases of patients with IgA nephropathy with mild to moderate proteinuria, normal kidney function and syndrome of blood stasis due to qi deficiency were enrolled. By using single case randomized controlled design, Modified Huangqi Chifeng Decoction combined with Telmisartan was applied in the treatment period and single Telmisartan was applied in the control period. The efficacy indices were 24-hour urine protein quantification and TCM symptom scores, the safety indices were liver and kidney function and blood routine examination. Results The TCM symptom scores of each case in the treatment period were significantly reduced in different degrees compared with those of control period （P 〈 0.05）; after TCM symptom scores of 5 patients were integrated, the treatment period was significantly improved compared with those of control period （P 〈 0.05）. The 24-hour urine protein quantification of each patient in the treatment period was significantly lower than those of control period （P 〈 0.05）, after 24-hour urine protein quantification of 5 patients was integrated, the treatment period was significantly less than that of control period （P 〈 0.05）. Conclusion Modified Huangqi Chifeng Decoction in treatment of proteinuria due to IgA nephropathy is safe and effective, and it is feasible to use single case randomized control design in clinical research of TCM.

关 键 词：加味黄芪赤风汤 IGA肾病 蛋白尿 单病例随机对照 

分 类 号：R692.9[医药卫生—泌尿科学]