缺氧缺血性脑病新生儿心肌酶谱的变化分析及其与窒息后脑损伤的关系  

Changes of myocardial zymogram in neonates with hypoxic ischemic encephalopathy and its relationship with brain injury after asphyxia

作　　者：陈旭升 黄壁君 赵璇珠 

机构地区：[1]广东省汕头市龙湖区第二人民医院儿科,广东汕头515041

出　　处：《中国当代医药》2018年第2期89-91,共3页China Modern Medicine

摘　　要：目的分析缺氧缺血性脑病(HIE)新生儿的心肌酶谱变化情况及其和窒息后脑损伤的关系。方法收集我院在2015年2月~2017年2月收治的HIE患儿76例,按照其病情严重程度分为轻度组26例、中度组30例和重度组20例。对所有患儿均使用全自动生化分析仪检测,分析其心肌酶谱水平。在三组治疗后,需将其分为预后佳组70例和预后差组6例,对两组患者的心肌酶谱水平进行收集和比较。结果随着病情严重程度的不断提升,HIE患儿的心肌酶谱水平会呈不断上升趋势,和心肌酶谱成显著正相关(r=0.485,P<0.05)。预后差组患者的心肌酶谱水平均明显高于预后佳组,差异有统计学意义(P<0.05)。结论 HIE的发生发展会导致心肌酶谱出现较大变化,因此通过分析心肌酶谱的变化能够较好地判断HIE患者的病情严重程度,尤其是可准确了解其窒息后脑损伤情况,也能够指导分析其预后,有较高的临床使用价值。Objective To analyze the changes of myocardial zymogram in neonates with HIE and its relationship with brain injury after asphyxia.Methods 76 children with HIE in our hospital from February 2015 to February 2017 were collected.According to their severity,they were divided into mild group 26 cases,moderate group 30 cases and severe group 20 cases.All the children were detected by automatic biochemical analyzer, and the level of myocardial zymogram was analyzed.After two groups of treatment were completed,they were divided into 70 groups with good prognosis and 6 cases with poor prognosis.The levels of myocardial enzymes were collected and compared between the two groups.Results With the increase of the severity of the disease,the myocardial zymogram level of HIE patients showed a rising trend,and showed a significant positive correlation with myocardial enzyme spectrum （r=0.485,P〈0.05）.The myocardial zymogram level of the patients with poor prognosis was significantly higher than that of the prognosis group,the difference was statistically significant （P〈0.05）.Conclusion The occurrence and development of HIE will lead to a larger change of myocardial enzyme spectrum,so by analyzing the changes of myocardial enzyme spectrum can determine the severity of the HIE patients.Especially,it can accurately understand brain injury,also can guide the analysis of the prognosis,with a high clinical value.

关 键 词：缺氧缺血性脑病新生儿 心肌酶谱变化 窒息后脑损伤 关系 

分 类 号：R722.1[医药卫生—儿科]