氟苯尼考增溶方法的研究进展  

Advances on Improving the Solubility of Florfenicol

作　　者：梁劲康 吴志玲 吴广辉 梁惠莲 张桂君 方炳虎 

机构地区：[1]广东温氏大华农生物科技有限公司,广东云浮527400 [2]华南农业大学兽医学院,广州510642

出　　处：《中国兽药杂志》2018年第1期69-76,共8页Chinese Journal of Veterinary Drug

基　　金：国家重点研发计划项目(2017YFD0501400);广东省战略性新兴产业核心技术攻关项目(2012A020800004);广东温氏大华农生物科技有限公司科研基金项目

摘　　要：氟苯尼考抗菌谱广且安全有效,由于其在水中的溶解度极低,限制了在动物临床的使用。近年来,研究学者运用各种物理或化学方法改善氟苯尼考的溶解度,从而提高其生物利用度。对大量文献的分析与总结,主要介绍几种改善氟苯尼考溶解度的方法,以期为更好地开发氟苯尼考制剂提供一定参考。As a safe and broad-spectrum antimicrobial drug, livestock. However, the solubility of florfenicol in water was florfenicol had been widely used in aquaculture and very low, which limited its clinical usage. Different kinds of physical or chemical methods had been developed to improve the solubility and bioavalibility of florfenicol in recent years. In this paper, the current solubilization development of florfenicol was reviewed through the summary and ananlysis of various literatures. This paper could also provide a reference for the preparation of flor- fenicol.

关 键 词：氟苯尼考 溶解度 溶出速度 生物利用度 

分 类 号：S859.796[农业科学—临床兽医学]