2型糖尿病与其相关指标对肝细胞癌患者总生存率的影响  

The Effect of T2DM and Related Indexes on the Overall Survival Rate of Patients With HCC

作　　者：刘亭[1,2] 庞雅玲 张华[1,2] 王养维[1] LIU Ting;PANG Yaling;ZHANG Hua;WANG Yangwei(Department of Endocrinology, Shanxi Provincial People’s Hospital, Xi＇an Shanxi 710068, China;Graduate School of Medical College, Yan＇an University, Yan＇an Shanxi 716000, China)

机构地区：[1]陕西省人民医院内分泌科,陕西西安710068 [2]延安大学医学院研究生院,陕西延安716000

出　　处：《中国继续医学教育》2017年第34期58-59,共2页China Continuing Medical Education

摘　　要：目的探讨2型糖尿病(T2DM)及其相关指标对肝细胞癌患者总生存率的影响。方法临床纳入2005年1月—2015年12月某三甲医院住院期间首次确诊的肝癌患者共463例。采用单因素(log-rank检验)及多因素(Cox比例风险回归)生存分析方法。结果存活组与死亡组的血糖波动相比,差异有统计学意义(P<0.05)。使用单因素log-rank检验发现空腹血糖水平、低血糖的发生、T2DM病程、使用胰岛素均与T2DM合并肝癌患者的生存率有关(P<0.05)。结论 T2DM及其相关指标可能是肝癌患者预后不良的独立因素。Objective To investigate the effect of type 2 diabetes mellitu（T2DM） on the overall survival rate of patients with hepatocellulacarcinoma （HCC）. And its correlation with the overall survival rate opatients with T2DM complicated with HCC. Methods A total of 46patients with HCC admitted to our hospital from January 2005 to Decembe2015 were enrolled in this study. Univariate and multivariate survivaanalysis were selected. Results There was a signifcant difference betweethe survival group and the death group （P〈0.05）. Fasting blood glucosehypoglycemia, duration of diabetes, and insulin use were associatewith survival in patients with T2DM complicated with HCC （P〈0.05）Conclusion T2DM and related indexes may be independent prognostifactors in patients with HCC.

关 键 词：2型糖尿病 肝细胞癌 CHILD-PUGH分级 TNM分期 生存率 

分 类 号：R587[医药卫生—内分泌]