辛伐他汀联合比索洛尔治疗老年不稳定型心绞痛的药理研究  

Research on Clinical Pharmacodynamics of Simvastatin Plus Bisoprolol for Aged Patients With Unstable Angina Pectoris

作　　者：刘跃林[1] 沈安明[1] LIU Yuelin;SHEN Anming(Pharmacy Department, Rugao Chinese Medicine Hospital, Rugao Jiangsu 226500, Chin)

机构地区：[1]如皋市中医院药剂科,江苏如皋226500

出　　处：《中国继续医学教育》2017年第35期67-69,共3页China Continuing Medical Education

摘　　要：目的观察辛伐他汀联合比索洛尔治疗老年不稳定型心绞痛的临床疗效与安全性。方法选择我院2014年1月—2016年1月80例老年不稳定型心绞痛病例,随机分为观察组与对照组各40例;对照组给予抗血小板、抗凝、抗缺血、他汀类及ACEI类等药物治疗,其中他汀类药物使用普伐他汀,β受体阻滞剂使用普萘洛尔;观察组用药方案与对照组基本相同,其中他汀类药物使用辛伐他汀,β受体阻滞剂使用比索洛尔。对两组治疗6周后临床疗效及不良反应发生率进行对比分析。结果观察组临床总有效率高于对照组(97.5%vs.82.5%,P<0.05)。两组用药后不良反应差异无统计学意义(P>0.05)。结论辛伐他汀联合比索洛尔治疗老年不稳定型心绞痛临床药效显著,且未见不良反应增加,具有较高的临床应用价值。Objective To explore the effects and security of simvastatin plus bisoprolol in the treatment of aged patients with unstable angina pectoris. Methods 80 aged patients with unstable angina pectoris from January 2014 to January 2016 were selected and divided into observation group （n=40） and control group （n=40）. The control group was treated with antiplatelet, anticoagulant, anti ischemic, statins and ACEI, etc. Statins were pravastatin, the beta blocker was propranolol. The treatment regimen of the observation group was the same as that in the control group. The statins were simvastatin, and the beta blocker was bisoprolol. The effects and adverse reactions in the two groups were compared. Results The effects in observation group were significant higher than control group （97.5%vs.82.5%, P 〈 0.05）. No signifcant difference of adverse reaction showed in the two groups （P 〉 0.05）. Conclusion The effects of simvastatin and bisoprolol were more signifcant than simvastatin solely without more adverse reaction for aged patients with unstable angina pectoris.

关 键 词：辛伐他汀 比索洛尔 临床药效学 老年不稳定型心绞痛 

分 类 号：R541[医药卫生—心血管疾病]