血管外膜成纤维细胞在动脉粥样硬化及PCI后再狭窄中的作用  

The Role of Adventitial Fibroblast in Atherosclerosis and Restenosis Post-PCI

作　　者：李彤[1] 赵明镜[1] 韩小婉[1] 赵一舟[1] 杨涛[1] 王蕾[1] 王保福 张菁 京继 Li Tong;Zhao Mingjing;Han Xiaowan;Zhao Yizhou;Yang Tao;Wang Lei;Wang Baofu;Zhang Jing;Jing Ji(Key Laboratory of Chinese Internal Medicine of Ministry of Education ＆ Beijing, Cardiovascular Institute, Laboratory for IntegratedChinese and Western Medical Research of Qi Blood, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Bei-jing 100700, China)

机构地区：[1]北京中医药大学东直门医院中医内科学教育部和北京市重点实验室、北京中医药大学心血管研究所、中西医结合气血研究实验室,北京100700

出　　处：《中西医结合心脑血管病杂志》2018年第1期49-53,共5页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：国家自然科学基金项目(No.81173234)

摘　　要：血管外膜是动脉粥样硬化(AS)和经皮冠状动脉介入治疗(PCI)后再狭窄等血管重构疾病的"积极参与者"。血管外膜不仅发挥简单的支持血管、提供营养物质的作用,越来越多的研究表明,外膜还主动参与了AS和PCI后再狭窄的病理过程。作为血管外膜最重要的组成部分,外膜成纤维细胞(AF)通过活化、增殖、迁移,分泌细胞因子和细胞外基质导致血管外膜和内膜的增厚和管腔狭窄。另外,AF活化后还通过参与一氧化氮的调节、氧化应激和炎症反应等促进AS和PCI后再狭窄的形成。The vascular adventitia is an active participant of vascular remodeling diseases like atherosclerosis（AS）and restenosis post-PCI.More and more researches indicated that adventitia not only plays a supporting and nutritional role to blood vessels,but also participates in the process of AS and restenosis post-PCI.As the most important component of adventitia,the adventitial fibroblast results in thickening of adventitia and intima,and luminal stenosis by activating,proliferating,migrating,secreting cytokines and extracellular matrix.In addition,activated fibroblast also promotes the formation of AS and restenosis post-PCI by taking part in the regulation of nitric oxide,oxidative stress and inflammatory response.This review presents the new research trends and development on the role of adventitial fibroblast in atherosclerosis and restenosis post-PCI.

关 键 词：动脉粥样硬化 血管外膜成纤维细胞 经皮冠状动脉介入治疗 再狭窄 病理机制 

分 类 号：R543[医药卫生—心血管疾病] R259[医药卫生—内科学]