钴催化的一步法贝克曼重排反应  

Cobalt-catalyzed One-pot Beckmann Rearrangement

作　　者：黄相韵 虞姜姜 张斌[1] 姚武冰 

机构地区：[1]台州学院,浙江台州318000

出　　处：《广州化工》2018年第1期48-50,共3页GuangZhou Chemical Industry

基　　金：国家级大学生创新创业训练计划项目(No:201710350018)

摘　　要：传统的贝克曼重排反应需使用强酸作为促进剂,反应条件苛刻、环境污染严重。为了改善这种情况,需发展新型廉价金属催化体系实现绿色的贝克曼重排反应,因此利用廉价易得的氟硼酸钴水合物,在温和、空气环境且不添加添加剂的条件下,首次实现钴催化酮类衍生物和盐酸羟胺的一步法贝克曼重排反应,产物收率最高为95%,反应体系中无溶剂及添加剂,反应体系的原子经济性和底物普适性较好。The traditional Beckmann rearrangement reactions generally require high temperature and strong acids,and suffer from harsh conditions and serious environmental pollution. In order to improve this situation,it is necessary to develop a new commercial metal catalyst system to achieve the green Backman rearrangement reaction. Based on the efficient and commercial available cobalt tetrafluoroborate hexahydrate,the catalyst systems capable of highly efficient catalytic Beckmann rearrangement of ketone and hydroxylamine hydrochloride in a one-pot process were developed,offering the yield of products up to 95%. This novel system proceeded with additives and solvent free,and showed high atom-economy and well functional-group tolerance.

关 键 词：贝克曼重排 钴催化剂 酮 酰胺 

分 类 号：O626.4[理学—有机化学]