清膈养阴颗粒澄清工艺研究  

Study on Clarification Procedure of Chitosan of Qing Ge Yang Yin Granules

作　　者：丁军 陈永荣[1] 刘国彬[1] 陈金锋[1] 姜蕾[1] 

机构地区：[1]六安市中医院药剂科,安徽六安237000

出　　处：《广州化工》2018年第1期100-101,141,共3页GuangZhou Chemical Industry

摘　　要：在保留清膈养阴颗粒提取液主要成分的基础上,去除不必要的杂质,以减少服用量,提高患者顺从性。以干浸膏得率和绿原酸含量为指标,通过正交试验法考察提取液浓缩比(药液体积∶生药克数)、壳聚糖加入量、澄清温度、搅拌时间对澄清工艺的影响,研究清膈养阴颗粒提取液的澄清工艺。最终确定的最佳澄清工艺为:提取液浓缩比6∶1,60℃下搅拌15 min,加入0.8 m L/g生药的壳聚糖絮凝液。Aimed to retain Qing Ge Yang Yin Granules extract on the basis of main component,remove unnecessary impurities,reduce dosage and improve patients' compliance,by means of determining dry extract yield and the content of chlorogenic acid,orthogonal experiment was used to study the four factors,including the amount of chitosan,enrichment ratio,the flocculation temperature and mixing time. The optimal clarification procedure was obtained under these conditions,enrichment ratio was 6∶1,mixing with 0. 8 m L·g^1 chitosan solution for 15 minutes at 60 ℃.

关 键 词：清膈养阴颗粒 绿原酸 干浸膏得率 正交设计 

分 类 号：R94[医药卫生—药剂学]