尿视黄醇结合蛋白、转化生长因子β1和转铁蛋白对妊娠期高血压疾病肾损害的诊断意义  

Urinary retinol-binding protein,transforming growth factor-β1 and transferrin in diagnosis of renal damage of gestational hypertension

作　　者：马睿[1] 刘洁[1] 成佳景[1] 周健红[1] MA Rui;LIU Jie;CHENG Jia-jing;ZHOU Jian-hong(Dept. of Obstetrics and Gynecology, Tenth People＇s Hospital, Tongji University, Shanghai 200072, Chin)

机构地区：[1]同济大学附属第十人民医院妇产科,上海200072

出　　处：《同济大学学报（医学版）》2017年第6期97-101,共5页Journal of Tongji University(Medical Science)

摘　　要：目的观察尿视黄醇结合蛋白(retinol-binding protein,RBP)、转化生长因子β1(transforming growth factor-β1,TGF-β1)和转铁蛋白对妊娠期高血压综合征肾损害的诊断意义。方法选择2015年1月~2016年12月在我院就诊的妊娠高血压综合征患者96例为妊娠高血压组。根据妊高症的严重程度分为轻度29例,中度36例和重度31例。按照内生肌酐清除率分为肾功能正常组51例和肾功能异常组45例。选择同期在我院正常体检孕妇60例。用ELISA的方法测定尿RBP,TGF-β1和转铁蛋白水平。比较妊娠高血压组和正常妊娠组尿RBP,TGF-β1和转铁蛋白水平,妊娠高血压患者尿RBP,TGF-β1和转铁蛋白水平与妊娠高血压严重程度和肾功能异常的关系,及各指标之间的相互关系。结果妊娠高血压组的尿RBP、TGF-β1和转铁蛋白水平明显高于正常妊娠组,差异有统计学意义(P<0.01)。尿RBP、TGF-β1和转铁蛋白水平随着妊娠高血压严重程度的增加而增加(P<0.01),肾功能异常组尿RBP、TGF-β1和转铁蛋白水平明显高于肾功能正常组(P<0.01)。妊娠高血压患者尿RBP水平与TGF-β1(r=0.756,P<0.05)和转铁蛋白(r=0.841,P<0.05)水平呈正相关,而尿TGF-β1水平与尿转铁蛋白水平呈正相关(r=0.654,P<0.05)。结论尿RBP、TGF-β1和转铁蛋白水平与妊娠高血压严重程度相关,对妊娠期高血压疾病患者肾损害的诊断具有重要临床意义。Objective To assess the diagnostic value of urinary retinol-binding protein(RBP),transforming growth factor-β1(TGF-β1) and transferrin in renal injury of pregnancy-induced hypertension syndrome(PIH).Methods Ninety six PIH patients admitted in our hospital from January 2015 to December 2016 were enrolled in the study.Among 96 patients,there were 29 mild cases,36 moderate cases and 31 severe cases according to the severity of gestational hypertension; and there were 51 cases with normal renal function and 45 cases of renal dysfunction according to endogenous creatinine clearance rate.Sixty normal pregnant women were selected as control group.Urinary RBP,TGF-β1 and transferrin levels were determined by ELISA.The relationship of RBP,TGF-β1 and transferrin levels with the severity of pregnancy-induced hypertension and renal dysfunction were analyzed.Results The levels of RBP,TGF-β1 and transferrin in PIH patients were significantly higher than those in control group(P < 0.01).Urinary RBP,TGF-β1 and transferrin levels were increased with the severity of pregnancy-induced hypertension(P < 0.01).Urinary RBP,TGF-β1 and transferrin levels were significantly higher in patients with renal dysfunction than those with normal renal function(P < 0.01).Urinary RBP levels were positively correlated with urinary TGF-β1(r = 0.756,P < 0.05) and transferrin(r = 0.841,P < 0.05).Urinary TGF-β1 levels were positively correlated with urinary transferrin(r = 0.654,P < 0.05).Conclusion Urinary RBP,TGF-β1 and transferrin are related to the severity of PIH and renal function,suggesting that these indicators may be used for diagnosis of renal injury in patients with gestational hypertension.

关 键 词：妊娠期高血压疾病 视黄醇结合蛋白 转化生长因子Β1 转铁蛋白 

分 类 号：R714.2[医药卫生—妇产科学]