精子质量异常患者染色体变异分析  

Analysis of chromosomal variation in patients with abnormal sperm quality

作　　者：路兴军[1] 李晓东[1] 孙立宁[1] 陶华娟 王磊[1] 

机构地区：[1]潍坊市妇幼保健院,潍坊261011

出　　处：《生殖医学杂志》2018年第2期155-158,共4页Journal of Reproductive Medicine

基　　金：潍坊市卫生计生委科研项目计划(2016wsjs029)

摘　　要：目的探讨染色体变异与少精子症、畸形精子症和无精子症的关系。方法选取2015年6月至2017年6月于本院就诊的原发不育男性患者211例,根据精液常规检测结果分为少精子症组(107例)、畸形精子症组(60例)和无精子症组(44例),以同期140例精液常规正常男性作为对照组,抽取外周血进行染色体核型分析,并比较不同组间染色体异常分布。结果畸形精子症组和无精子症组染色体畸变率(5.0%和9.1%)高于正常对照组(1.4%),差异均有统计学意义(P均<0.05);少精子症组染色体畸变率(2.8%)与对照组(1.4%)比较差异无统计学意义(P>0.05);各组间染色体多态率比较差异均无统计学意义(P>0.05)。结论染色体畸变是导致畸形精子症和无精子症的重要因素之一,对于此类患者进行外周血染色体检查,有助于查找病因、明确诊断。Objective： To explore the relationship between chromosomal variation and semen quality. Method.A total of 211 primary infertile men were enrolled in our hospital from June 2015 to June 2017. According to the results of routine semen analysis, the patients were divided into three groups= oligozoospermia group （n = 107）, teratozoospermia （n = 60） and azoospermia group （n = 44）. In the same period, 140 men with normal semen served as the control group. Peripheral blood samples were collected for karyotype analysis,and chromosomal abnormalities were compared between groups. Results. The chromosome mutation rate of in patients with teratozoospermia and azoospermia groups was 5.0% and 9.1% respectively, which was significantly higher than that in the normal semen group （1.43%） （P 〈 0.05）.There was no significant difference in chromosomal mutation rate between oligospermia group （2.8%） and control group（1.4%） （P〉0.05）. There was no significant difference in the incidence chromosomal polymorphism among the groups（P〉0. 05）. Conclusions. Chromosomal mutation is one of the important causes of teratozoospermia and azoospermia. Peripheral blood chromosome examination can help to find the cause and definite diagnosis for such patients.

关 键 词：少精子症 畸形精子症 无精子症 染色体 

分 类 号：R698.2[医药卫生—泌尿科学]