柴甘解忧汤治疗帕金森病抑郁35例  

The clinical efficacy of Parkinson′s disease depression treated with Chaigan Jieyou decoction

作　　者：马丹丹 雒晓东[2] 郑春叶[2] 

机构地区：[1]郑州大学第三附属医院,郑州450002 [2]广东省中医院,广州510120

出　　处：《实用医学杂志》2018年第1期144-147,共4页The Journal of Practical Medicine

基　　金：2017河南省医学科技攻关项目(编号:201702108);广东省中医院朝阳人才专项(编号:2014KT1325)

摘　　要：目的客观评价柴甘解忧汤对帕金森病抑郁(PDD)的临床有效性。方法采用随机对照方法,选择2014-2016年收集的70例符合研究标准的患者,按数字表法随机分成柴甘解忧汤组和氟西汀组各35例,柴甘解忧汤组给予柴甘解忧汤汤剂,氟西汀组给予盐酸氟西汀胶囊,连续应用8周。治疗前及治疗后采用汉密尔顿-17项(HAMD-17)、Beck抑郁自评量表(BDI)、帕金森综合评分量表(UPDRS)Ⅱ、Ⅲ部分及中医症候评定量表评价临床疗效。结果两组以HAMD评分减分率比较,总有效率差异无统计学意义(P>0.05);以中医症候疗效比较,柴甘解忧汤组疗效优于氟西汀组(P<0.05);两组治疗后HAMD、BDI、UPDRSⅡ、UPDRSⅢ评分差值均有统计学差异(P<0.01或P<0.05);以中医症候主要症状评分比较,柴甘解忧汤组疗效优于氟西汀组;以HAMD评分对不同程度患者的疗效比较,柴甘解忧汤组可减轻轻中度PDD患者的临床症状。结论柴甘解忧汤可明显缓解PDD患者的临床抑郁症状,对于轻、中度PDD患者疗效确切,并可在一定程度上改善其生存质量。Objective To evaluate the clinical efficacy and safety of Chaigan Jieyou decoction in treating Parkinson＇s disease depression （PDD）. Methods Applying the method of simple random contrast, this research collects 70 patients who meet the study criteria and divide the patients into two groups of 35 peoples each ： Chaigan Jieyou decoction group, which received treatment of Chaigan Jieyou decoction and tluoxetine group with treatment of fluoxetine. Treatment period was 2 months. Apply the HAMD-17 （Hamilton Depression Scale） , Beck Depression Scale （Beck Depression Inventory, BDI）, Parkinson＇s composite score （unified Parkinson disease rating scale, UPDRS） and TCM symptoms rating scale to evaluate the clinical efficacy before and after treatment. Resuits Compared the two groups by HAMD Score reduction rate, there is no statistical significance in the general ef- ficacy rate （P 〉 0.05） ; compared by the curative effect of TCM syndrome, Chaigan Jieyou decoction group is better than fluoxetine group （P 〈 0.05）. There is statistical significance in the differences of all the HAMD, BDI, UPDRS Ⅱ, UPDRS Ⅲ scores between the two groups after the treatment （P 〈 0.01, P 〈 0.05）. Compared the treatment effi- cacy by the HAMD scores, Chaigan Jieyou decoction can alleviate the clinical symptoms of patients of varying degrees. Conclusions Chaigan Jieyou decoction can significantly relieve depression of PDD patients, and there is ex- act curative effect to the mild and moderate PDD patients, improving their quality of life to a certain extent.

关 键 词：柴甘解忧汤 帕金森病抑郁 临床疗效 

分 类 号：R277.7[医药卫生—中医学]