托特罗定联合缩泉丸加减治疗绝经后妇女膀胱过度活动症的临床疗效观察  

Effect of tolterodine combined with Suoquan pill on overactive bladder in postmenopausal women

作　　者：鹿英强[1] 李大勇[1] 王丽霞[1] 袁明殿[1] 

机构地区：[1]辽宁中医药大学附属医院泌尿外科,沈阳110032

出　　处：《广西医科大学学报》2018年第1期45-48,共4页Journal of Guangxi Medical University

基　　金：国家自然科学基金资助项目(No.81173273)

摘　　要：目的:探讨托特罗定联合缩泉丸加减应用于绝经后妇女膀胱过度活动症(OAB)的临床效果。方法:选取2015年1月至2016年12月辽宁中医药大学附属医院收治的40例绝经后女性OAB患者,随机分为观察组和对照组,每组20例。对照组采用托特罗定治疗,观察组在对照组基础上加用缩泉丸治疗。比较两组临床疗效、生活质量评分(QOL)、膀胱过度运动症状量表评分(OABSS)、尿流率参数及血清雌二醇(E2)、卵泡生成激素(FSH)水平。并观察治疗过程中的不良反应。结果:观察组治疗总有效率为90.00%,显著高于对照组的70.00%(P<0.05)。治疗后,观察组排尿量(VV)、平均尿流率(Qava)、最大尿流率(Qmax)及血清FSH水平均显著高于治疗前及对照组(P<0.05),QOL评分及OABSS评分明显低于治疗前及对照组(P<0.05),而两组E2水平比较差异无统计学意义(P>0.05)。观察组不良反应发生率明显低于对照组(P<0.05)。结论:托特罗定联合缩泉丸加减应用于绝经后妇女OAB患者,可有效提高临床疗效,改善患者的临床症状,并降低不良反应的发生率。Objective： To investigate the clinical effect of tolterodine combined with Suoquan pill on overactive bladder （OAB） in postmenopausal women. Methods： From January 2015 to December 2016, 40 OAB postmenopausal women treated in our hospital were selected and randomly divided into an observation group and a control group, with 20 cases in each group. The patients in the control group received tolterodine treatment, and those in the observation group were treated as the control group with addition of Suoquan pill. The clinical effect, the quality of life, OAB symptom scores, urinary flow rate, and the levels of estradiol and follicle-stimulating hormone （FSH） in serum were compared. Results： The total response rate in the observation group was significantly higher than that in the control group （P〈0. 05）. After treatment, urinary output, mean urinary flow rate, maximum flow rate and serum FSH level were significantly increased in the observation group, compared with the control group （P〈0. 05）. The QOL and OABSS scores in the observation group were markedly lower than those in the control group （P〈 0. 05 ）, but no significant difference was found in the level of estradiol between the two groups （P〈 0.05）. Patients treated with Suoquan pill had lower risk of adverse reactions. Conclusion： Tolterodine combined with Suoquan pill for the treatment of OAB in postmenopausal women was effective. It could improve patients＇ clinical symptoms and reduce the incidence of adverse reactions.

关 键 词：缩泉丸 绝经后妇女 膀胱过度活动症 

分 类 号：R694[医药卫生—泌尿科学]