ST2在急性心力衰竭中的预后价值  

ST2 and prognosis in acute heart failure

作　　者：孟冲[1] 商德亚[1] 王娟[1] 

机构地区：[1]山东大学附属省立医院,山东济南250021

出　　处：《中国急救医学》2018年第1期41-45,共5页Chinese Journal of Critical Care Medicine

摘　　要：ST2与IL-33结合能够减少心肌纤维化，抑制心肌肥大，减少心肌凋亡及改善心脏功能。sST2可以欺骗性地与IL-33结合抑制心肌保护作用。截止目前，发现ST2在社区人群中的参考值范围与性别有关，与年龄关系不确切；ST2对于急性心力衰竭（AHF）的诊断价值不大，却能较好地独立预测AHF患者不良心血管事件的发生，尤其是死亡和心力衰竭再住院；连续监测ST2浓度可能预测价值更大，而且有可能在指导治疗方面发挥重要作用。ST2 could reduce myocardial fibrosis, inhibit myocardial hypertrophy, prevent myocardial apoptosis and improve heart function by the binding of IL - 33. sST2 avidly binds IL - 33 which results in interruption of the cardioprotective interaction. At present, firstly, ST2 in community population is certainly related to gender, but unclearly to age. Moreover, the diagnostic value of ST2 is negligible in patients with acute heart failure, but it can independently predict adverse cardiovascular events in those, especially the death and rehospitalization for worsen heart function. The last, serial measurement of the ST2 might play an important role in the prognosis and guidance of treatment.

关 键 词：急性心力衰竭(AHF) ST2 预后 

分 类 号：R541.6[医药卫生—心血管疾病]