中国人群慢性阻塞肺病相关危险因素的Meta分析  

Meta analysis on risk factors related to chronic obstructive lung disease in Chinese population

作　　者：林传钦 翟秀丽 邓托 

机构地区：[1]海南省农垦三亚医院急诊科,海南三亚572000 [2]海南省三亚市三林医院

出　　处：《实用预防医学》2018年第2期191-194,共4页Practical Preventive Medicine

基　　金：三亚市医疗科技创新项目(YW1214)

摘　　要：目的探讨影响中国人群慢性阻塞肺病相关危险因素的Meta分析。方法收集2000-2015年我国公开发表的关于中国人群慢性阻塞肺病相关危险因素的研究文献资料共14篇。应用Rev Man 5.0软件进行Meta分析。结果吸烟、有被动吸烟史、BMI、职业粉尘或化学品暴露、家族呼吸道疾病史、儿童时期呼吸道疾病史、受教育程度、使用煤及柴草燃料及厨房通风情况与慢性阻塞肺病OR值之间存在关联,且均为危险因素。根据其OR估计值的大小,吸烟3.08(95%CI:2.26,4.21)、使用煤及柴草燃料3.10(95%CI:1.77,3.71)、家族呼吸道疾病史3.42(95%CI:2.76,3.98)与慢性阻塞肺病OR值呈较强的关联强度,被动吸烟1.46(95%CI:1.15,1.98)、职业粉尘或化学品暴露1.57(95%CI:1.17,2.45)、厨房通风情况1.28(95%CI:1.82,2.43)与慢性阻塞肺病OR值呈较弱关联,其他因素均呈中等强度关联。男性、高龄与慢性阻塞肺病OR值无相关。采用固定效应模型和随机效应模型分别计算慢性阻塞肺病发病危险因素的OR合并值及95%CI,结果两种模型分析结果基本相似。结论吸烟、有被动吸烟史、BMI、职业粉尘或化学品暴露、家族呼吸道疾病史、儿童时期呼吸道疾病史、受教育程度、使用煤及柴草燃料及厨房通风情况是影响中国人群慢性阻塞肺病发病的危险因素。Objective To explore the risk factors associated with chronic obstructive lung disease in Chinese population by Me- ta analysis. Methods We collected a total of 14 domestic published studies regarding the risk factors related to chronic ob- structive lung disease among Chinese population during 2000-2015, and then Meta analysis was performed by using Rev Man 5.0 software. Results Smoking, passive smoking history, body mass index （BMI）, occupational dust or chemical exposure, family history of respiratory disease, childhood respiratory disease history, educational background, use of coal and straw fuel and kitchen ventilation were correlated with the OR value of chronic obstructive pulmonary disease; moreover, they were all risk factors. Ac- cording to the OR estimated values, smoking （3.08, 95%CI： 2.26-4.21 ）, use of coal and straw fuel （3.10, 95%C1：1.77-3.71 ） and family history of respiratory disease （3.42, 95%CI： 2.76-3.98） showed a strong correlation with the OR value of chronic ob- structive pulmonary disease（ COPD）, while passive smoking （ 1.46, 95%CI： 1.15-1.98） , occupational dust or chemical exposure （1.57, 95%CI： 1.17-2.45） and kitchen ventilation （1.28, 95%CI： 1.82-2.43） showed a slight correlation with the OR value of COPD. And other factors displayed a moderate correlation with the OR value. Male and age were not associated with the OR value. The fixed effect model and random effect model were used to respectively calculate the OR combined value and 95%C1 of risk fac- tors for COPD and got basically similar results. Conclusions Smoking, passive smoking history, BMI, occupational dust or chemical exposure, family history of respiratory disease and childhood respiratory disease history, educational background, use of coal and straw fuel and kitchen ventilation are the risk factors affecting the occurrence of chronic obstructive pulmonary disease in Chinese population.

关 键 词：慢性阻塞肺病 病例对照研究 危险因素 META分析 

分 类 号：R563[医药卫生—呼吸系统]