血清NT-proBNP与IL-6在川崎病患儿中的水平变化及临床意义  

Changes and clinical significance of serum NT-proBNP and IL-6 levels in children with Kawasaki disease

作　　者：江雅静 赵玉岐[1] 王鹤[1] 钱程 刘昱[1] 

机构地区：[1]沧州市中心医院儿科,河北沧州061000

出　　处：《实用预防医学》2018年第2期199-201,245,共4页Practical Preventive Medicine

基　　金：河北省沧州市2015年科技计划项目(151302153)

摘　　要：目的探讨血清N末端B型脑钠肽原(NT-proBNP)、白细胞介素-6(IL-6)在川崎病(KD)患儿中的表达水平及临床意义。方法收集2014年8月-2016年12月沧州市中心医院收治的KD患儿为病例组(n=50),并根据是否合并冠脉损伤将其分为冠脉损伤组(n=17)和非冠脉损伤组(n=33),并于同期选取因发热性疾病入院治疗的非KD患儿为对照组(n=50)。采用电化学发光法检测血清NT-proBNP水平,酶联免疫吸附法检测血清IL-6水平。结果病例组患儿血清NT-proBNP、IL-6水平均高于对照组,差异有统计学意义(P<0.05)。冠脉损伤组患儿血清NT-proBNP、IL-6水平均高于非冠脉损伤组,差异有统计学意义(P<0.05)。经Pearson积差相关分析,病例组患儿血清NT-proBNP与IL-6呈正相关关系(r=0.639,P<0.05)。NT-proBNP的ROC曲线下面积AUC为0.862(95%CI:0.755~0.970),最佳临界值为1.07μg/L,灵敏度为89.21%,特异性为92.24%;IL-6的ROC曲线下面积AUC为0.904(95%CI:0.813~0.995),最佳临界值为58.21 ng/ml,灵敏度为93.41%,特异性为89.16%;NT-proBNP联合IL-6对KD的AUC为0.915(95%CI:0.837~0.993),灵敏度为96.27%,特异度为92.24%。结论 NT-proBNP、IL-6在川崎病患儿血清中明显升高,早期联合检测可作为辅助诊断川崎病的重要指标。Objective To explore the expression levels and clinical significance of serum N-terminal pro-brain natriuretic pep- tide （NT-proBNP） and intedeukin-6 （IL-6} in children with Kawasaki disease （KD）. Methods Children with KD who were hospitalized in Cangzhou Central Hospital from August 2014 to December 2016 served as the case group （n= 50） , and then they were divided into coronary artery injury group （n= 17} and non-coronary artery injury group （n= 33} according to the coro- nary artery injury. At the same time, non-KD children who were hospitalized for febrile disease were selected as the control group {n= 50）. The serum NT-proBNP levels were detected by electrochemiluminescenee, and the serum IL-6 levels were determined by enzyme-linked immunosorbent assay. Results The serum NT-proBNP and IL-6 levels in the case group were both higher than those in the control group, showing a statistically significant difference （P〈0.05）. The serum NT-proBNP and IL-6 levels were both higher in coronary artery injury group than in non-coronary artery injury group, with statistically significant differences （P〈0.05}. Pearson＇s product-moment correlation analysis showed that serum NT-proBNP was positively correlated with IL-6 in the case group （r= 0.639, P〈0.05}. According to the receiver operating characteristic curve （ROC} analysis, the area under ROC curve （AUC） of NT-pro BNP for detection of KD was 0.862 （ 95%CI：0.755-0.970} , and the optimal cut-off value, sensitivity and specificity were 1.07 ug/L, 89.21% and 92.24% respectively. The AUC of IL-6 for detection of KD was 0.904 { 95%CI：0.813 -0.995） , and the optimal cut-off value, sensitivity and specificity were 58.21 ng/ml, 93.41% and 89.16% respectively. The AUC of NT-proBNP combined with IL-6 for detection of KD was 0.915 （ 95%C1：0.837-0.993 ） , with the sensitivity and specificity be- ing 96.27% and 92.24% respectively. Conclusions The serum NT-proBNP and IL-6 in children with KD are significantly in- creased; and he

关 键 词：N末端脑钠肽前体 白细胞介素-6 川崎病 

分 类 号：R725.4[医药卫生—儿科]