β-咔啉衍生物的抗肿瘤活性研究进展  

Progress in Antitumor Activities of β-Carboline Derivatives

作　　者：王京[1] 佘霞 徐阳 张磊[1] 

机构地区：[1]遵义医学院药学院,遵义563003

出　　处：《国外医药（抗生素分册）》2018年第1期74-79,共6页World Notes on Antibiotics

摘　　要：β-咔啉是一种重要的三环吲哚生物碱,广泛存在于多种生物中,如植物、动物和海洋生物。研究表明,β-咔啉具有多种重要的药理作用,其中包括抗肿瘤活性。为了提高β-咔啉的抗肿瘤活性,同时增强其水溶性和降低毒性,人们通过化学合成的方法构建了β-咔啉母核结构,并对其进行了大量的修饰改造,然后通过体内外活性研究,获得了一些具有显著抗肿瘤活性的先导化合物。本文主要综述了近年来β-咔啉衍生物的抗肿瘤活性研究进展,旨在为今后β-咔啉的研究提供有益的帮助。β-carboline is a kind of tricyclic indole alkaloids widely distributed in nature, such as plants, animals and marine life, which have important biological activities, especially potent anticancer activity. In order to improve the antitumor activity, increase solubility and decrease toxicity of β-carboline, the chemical synthesis of β-carboline nuclear structure was found, and a large number of structural modifications of β-carboline were prepared. Some potential lead compounds of β-carboline with excellent antitumor activity in vivo and in vitro were obtained in recent years. This paper reviewed the progress in anticancer activities of β-carbolines derivatives for further utilization of β-carbolines in future.

关 键 词：β-咔啉 衍生物 抗肿瘤活性 

分 类 号：R979.1[医药卫生—药品]