针刺对急性盆腔炎患者炎性因子的影响  

Effect of Acupuncture on Inflammatory Cytokines in Patients with Acute Pelvic Inflammatory Disease

作　　者：吴丹[1] 郭李燕[1] 卢佩斯[2] 

机构地区：[1]佛山市中医院妇科,广东佛山528000 [2]佛山市中医院针灸科,广东佛山528000

出　　处：《针刺研究》2018年第1期55-59,共5页Acupuncture Research

摘　　要：目的:观察针刺对急性盆腔炎患者炎性反应指标及临床疗效的影响,探讨针刺治疗盆腔炎的作用机制。方法:急性盆腔炎患者79例,采用数字表法随机分成对照组37例和观察组42例。对照组给予抗感染、止痛、营养支持等常规治疗,观察组在常规治疗的基础上,泻法针刺中极、关元、子宫、足三里、三阴交等穴,1次/d,共7d。观察两组患者治疗前后的白细胞计数(WBC)、中性粒细胞比例(NEU)、盆腔包块大小(PM)和盆腔积液深度(PE),测定并比较两组患者治疗前、治疗第3天、治疗第7天的血清肿瘤坏死因子-α(TNF-α)、白介素-10(IL-10)和C-反应蛋白(CRP)的水平,评估其临床疗效。结果:两组治疗后的WBC、NEU均较治疗前降低(P<0.05),观察组比对照组降低更显著(P<0.05)。两组治疗后的PM和PE均较治疗前缩小/减少(P<0.05),观察组治疗后的PM和PE较对照组缩小/减少更显著(P<0.05)。对照组在第7天的血清TNF-α和CRP均较治疗前、第3天降低(P<0.05),第3天的CRP低于治疗前(P<0.05);观察组的血清TNF-α和CRP在治疗后逐步降低(P<0.05),较对照组降低更显著(P<0.05)。观察组治疗第3、7天的血清IL-10均较治疗前升高(P<0.05),均高于对照组(P<0.05)。观察组的总有效率95.24%(40/42)显著高于对照组81.08%(30/37,P<0.05)。结论:针刺治疗能有效调节急性盆腔炎患者的血清炎性因子的表达,从而改善其临床症状。Objective To observe the effect of acupuncture on inflammatory indices and symptoms in patients with acute pelvic inflammatory disease, and investigate its mechanism. Methods Seventy-nine patients with acute pelvic inflammatory disease were randomly assigned to a control group （n = 37） given conventional treatment and an observation group （n = 42） given conventional treatment and acupuncture therapy. In the observation group, acupionts of Zhongji（OV 3）, Guanyuan（CV 4）, Zigong（EX-CA 1）, Zusanli（ST 36）, Sanyinjiao（SP 6）, etc. were selected. Each group received treatment once daily, for a total of 7 days. Tumor necrosis factor （TNF）-α, interleukin （IL）-10 and C-reactive protein （CRP） in the serum, white blood cell （WBC） and neutrophil counts, size of pelvic mass and depth of pelvic effusion, and clinical symptoms were assayed pretreatment and on days 3 and 7. Results WBC and neutrophils were significantly decreased after treatment in both groups （P〈0.05）, and more in the observation group than in the control group （P〈0.05）. After treatment, the size of pelvic mass and depth of effusion were less in both groups （P〈0.05）, and the efficacy in the observation group was superior to that in the control group （P 〈0. 05）. In the observation group, serum TNF-α, and CRP on day 3 and day 7 were significantly lower than those before treatment （P〈0.05）. Serum TNF-α and CRP were significantly down-regulated in the observation group compared with those in the control group on both day 3 and day 7 （P〈0.05）. In the observation group, serum IL-10 was higher on both day 3 and day 7 than that before treatment （P〈0.05）, and was statistically different from that in the control group on both days （P〈0.05）. The clinical efficacy in the observation group was superior to that in the control group （95.24% vs 81.08%, P〈0.05）. Conclusion Acupuncture can regulate the levels of inflammatory markers in patients with acute pelvic inflammatory diseas

关 键 词：针刺 急性盆腔炎 炎性因子 临床疗效 

分 类 号：R246.3[医药卫生—针灸推拿学]