变应原皮肤点刺试验结果与免疫治疗近期疗效相关性分析  

Influence of different levels of skin pricking test on the short-term efficacy of subcutaneous immunotherapy in allergic rhinitis

作　　者：刘燕[1] 林裕强 耿聪俐[1] 袁晓培[1] 王旻[1] 邢志敏[1] 

机构地区：[1]北京大学人民医院耳鼻喉科,北京100044

出　　处：《临床耳鼻咽喉头颈外科杂志》2018年第2期102-105,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨变应原皮肤点刺试验(SPT)阳性程度对变应性鼻炎皮下脱敏治疗短期疗效的影响。方法:通过症状和SPT确诊的单一尘螨过敏且完成1年皮下脱敏治疗的变应性鼻炎患者31例,男20例,女11例,年龄4~83岁,平均(41.97±19.83)岁。根据SPT阳性结果分为3组(2级,"++",10例;3级,"+++"10例;4级"++++",11例)。问卷调查皮下脱敏治疗1年后3组患者的VAS症状评分、用药评分及鼻结膜炎相关生活质量问卷评分。通过评分对比3组患者皮下脱敏治疗的短期疗效有无差异。结果:脱敏治疗1年后3组患者在VAS症状评分、生活质量评及分用药评分的总有效率分别为61.30%,58.06%,64.52%,均差异无统计学意义(P=0.573,0.136,0.699,P>0.05)。结论:SPT阳性程度不同的变应性鼻炎患者皮下脱敏均能获得良好的短期疗效,但其不能作为变应性鼻炎患者皮下脱敏治疗短期疗效的客观评价指标。Objective：To explore the effect of different levels of skin pricking test on short-term efficacy of subcutaneous immunotherapy with allergic rhinitis.Method：Thirty-one AR patients were included in our study.All the patients had received subcutaneous immunotherapy for 1 year.According to the levels of SPT the patients were divided into 3 groups（grade 2,10 persons;grade 3,10 persons and grade 4,11 persons）.Of all the patients,the nasal symptoms visual analogue scale（VAS）score,medication score and rhinoconjunctivitis quality of life questionnaire（RQLQ）were investigated both before and after receiving 1 year subcutaneous immunotherapy.Result：The total effective rate of VAS score,RQLQ score and medication score was 61.30%,58.06% and 64.52% respectively,but there was no statistical difference among the 3 groups after 1 year subcutaneous immunotherapy（P=0.573,0.136,0.699,P0.05）.Conclusion：This study confirms the short efficacy of subcutaneous immunotherapy in AR patients with different levels of SPT.But the level of SPT was not an objective index for shortterm efficacy of subcutaneous immunotherapy of AR.

关 键 词：鼻炎 变应性 皮肤点刺试验 皮下脱敏 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]