耳内镜下外耳道清理联合克霉唑软膏治疗妊娠期真菌性外耳道炎的疗效观察  

Effect observation of cleaning up the external auditory canal by otoendoscope combined with Clotrimazole Ointment in the treatment of pregnancy with otitis externa mycotica

作　　者：魏先梅[1] 陆玲[1] 高下[1] 

机构地区：[1]南京大学医学院附属鼓楼医院耳鼻咽喉头颈外科南京鼓楼医院耳鼻咽喉研究所,南京210008

出　　处：《临床耳鼻咽喉头颈外科杂志》2018年第2期134-137,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：江苏省医学重点学科(No:ZDXKB2016015);江苏省青年医学人才计划(No:QNRC2016002)

摘　　要：目的:探讨耳内镜下外耳道清理联合克霉唑软膏治疗妊娠期真菌性外耳道炎的临床疗效。方法:选取我院2015-05-2017-05期间门诊诊治的16例妊娠期真菌性外耳道炎患者,共19耳,按照不同的治疗方法分为单纯清理组和清理联合用药组。单纯清理组9例患者,共11耳,其中2例患者双耳发病,其余7例患者单耳发病,采用单纯常规耳内镜下外耳道清理;清理联合用药组7例患者,共8耳,其中1例患者双耳发病,其余6例患者单耳发病,常规耳内镜下清理外耳道后,耳内镜下外耳道内涂抹克霉唑软膏。两组患者各治疗2周,观察治疗结束后两组患者的临床疗效、不良反应、平均起效时间。结果:清理联合用药组的总有效率为100%,显著高于单纯清理组的81.81%,差异有统计学意义(P<0.05)。清理联合用药组平均起效时间较单纯清理组明显缩短[(2.71±0.70)d vs(5.40±1.96)d],差异有统计学意义(P<0.05)。两组患者均无明显不良反应。疗程结束后随访4周,单纯清理组复发1例,再次清理联合用药,2周治愈。结论:耳内镜下外耳道清理联合克霉唑软膏治疗妊娠期真菌性外耳道炎的临床疗效显著,安全性高,较单纯常规耳内镜下外耳道清理疗效更为理想,值得临床推广。Objective：To investigate the clinical effect of cleaning up the external auditory canal under otoendoscope combined with Clotrimazole Ointment in the treatment of pregnancy with otitis externa mycotica.Method：From May 2015 to May 2017,16 cases of pregnant patients（19 ears）with otitis externa mycotica were divided into two groups：pure cleaning up group and cleaning up combined with medication group.In the pure cleaning up group,external auditory canal were only cleaned up under otoendoscope conventionally in 9 patients（11 ears）,while in the cleaning up combined with medication group,Clotrimazole Ointment was topically applied after cleaning up the external auditory canal under otoendoscope in 7 patients（8 ears）.After treatment of 2 weeks,the clinical curative effect,adverse reaction and average time interval to take effect were compared at the end of treatment.Result：The total effective rate（100%）in cleaning up combined with medication group＇s was significantly better than that in pure cleaning up group＇s（81.81%）（P0.05）;The average time interval to take effect in cleaning up combined with medication groupwas significantly shorter than that in pure cleaning up group＇s[（2.71±0.70）d vs（5.40±1.96）d,P0.05].After the two-week treatment,there was a four-week follow-up.Only one patient in pure cleaning up group relapsed.After two-week treatment by Clotrimazole Ointment,this patient was cured.Conclusion：Cleaning up the external auditory canal under otoendoscope combined with Clotrimazole Ointment is effective and safe for the treatment of otitis externa mycotica in pregnant women.The addition of topical application of Clotrimazole Ointment further improve the therapeutic efficacy,as compared to the conventional method of cleaning up the external auditory canal under otoendoscope.We suggest clinical application of this method.

关 键 词：真菌性外耳道炎 妊娠期 克霉唑软膏 耳内镜 

分 类 号：R764.1[医药卫生—耳鼻咽喉科]