电针疗法对急性脑梗死患者的临床疗效及血清VEGF、NSE的影响  

Effects of electroacupuncture on clinical efficacy, serum vascular endothelial growth factor and neuron specific enolase in patients with acute cerebral infarction

作　　者：孙志欣[1] 李南南[1] 石磊[1] 

机构地区：[1]天津中医药大学第一附属医院,300193

出　　处：《天津医药》2018年第1期56-59,共4页Tianjin Medical Journal

基　　金：国家自然科学基金资助项目(81303021)

摘　　要：目的观察急性脑梗死患者电针治疗后的临床效果及血清血管内皮生长因子(VEGF)、神经元特异性烯醇化酶(NSE)的变化。方法选取本院神经内科2015年1月—2016年6月就诊的急性脑梗死患者96例,按照随机数字表法将患者分为对照组(48例)和电针组(48例),对照组患者给予常规治疗,电针组患者在常规治疗的基础上给予头针和体针结合的针刺疗法,治疗2周。比较2组患者治疗后临床疗效、神经缺损功能(NIHSS)评分、血清VEGF和NSE的水平。结果治疗2周后,电针组的临床有效率高于对照组(P<0.05)。治疗1周和2周后2组患者NIHSS评分、血清NSE水平较治疗前降低(P<0.05),电针组NIHSS评分和血清NSE水平均低于对照组(P<0.05)。治疗1周和2周后2组患者血清VEGF水平较治疗前升高(P<0.05),电针组血清VEGF水平高于对照组(P<0.05)。结论电针治疗能够促进急性脑梗死患者受损血管的再生和神经元的修复,提高患者的临床疗效,具有一定的临床意义。Objective To evaluate the effects of electroacupuncture on clinical efficacy, changes of serum vascularendothelial growth factor(VEGF) and neuron specific enolase(NSE) in patients with acute cerebral infarction.Methods From January 2015 to June 2016, 96 patients with acute cerebral infarction were selected and randomly divided into controlgroup(48 cases) and electroacupuncture group(48 cases). The control group was given routine treatment, and theelectroacupuncture group was given acupuncture combined with scalp acupuncture and body acupuncture on the basis ofroutine treatment for two weeks. The clinical efficacy, NIHSS score, serum VEGF and NSE levels were evaluated in twogroups of patients.ResultsAfter two weeks of treatment, the clinical effective rate was higher in electroacupuncture groupthan that of the control group(P<0.05). After one week and two weeks of treatment, the NIHSS score and serum NSE levelwere significantly decreased in both groups of patients compared with those before treatment(P<0.05). The NIHSS scoreand serum NSE level were lower in the electroacupuncture group than those in the control group(P<0.05). After one weekand two weeks of treatment, serum VEGF levels were significantly increased compared with those before treatment in the twogroups(P<0.05). The serum VEGF level was higher in electroacupuncture group than that in control group(P<0.05).ConclusionElectroacupuncture treatment can promote the regeneration of damaged blood vessels, repair neurons andimprove clinical efficacy in patients with acute cerebral infarction, which shows definite clinical significance.

关 键 词：脑梗死 电针 血管内皮生长因子类 神经元特异性烯醇化酶 

分 类 号：R278[医药卫生—中医学]