复发性流产患者再次妊娠率与子宫内膜容受性的相关性  

Correlation Between Re-pregnancy Rate and Endometrial Receptivity in Patients With Recurrent Spontaneous Abortion

作　　者：吕晓宇[1] 郑梅玲[2] 贺江梅[2] 张桂林[2] 化爱玲[2] 张红梅[2] 

机构地区：[1]山西医科大学,山西太原030001 [2]山西医科大学第一附属医院优生遗传室生殖中心,山西太原030001

出　　处：《中国卫生标准管理》2017年第28期35-36,共2页China Health Standard Management

摘　　要：目的探究复发性流产患者再次妊娠率与子宫内膜容受性的相关性。方法研究对象选取为2016年7—11月之间我院收治的30例复发性流产患者,设为研究组,选取同期正常妊娠妇女30例作为对照组,采用彩色多普勒超声检测两组黄体中期(排卵后5~7 d)的子宫内膜厚度和子宫内膜容积并对比,追踪观察研究组患者的妊娠结局,对比不同妊娠结局患者的子宫内膜厚度和子宫内膜容积差异,绘制ROC曲线,分析子宫内膜厚度和子宫内膜容积与复发性流产再次妊娠率的相关性。结果对照组的子宫内膜厚度和子宫内膜容积均显著高于研究组,差异具有统计学意义(P<0.05);随访1年,研究组再次妊娠患者的子宫内膜厚度和子宫内膜容积显著高于无再次妊娠者,差异具有统计学意义(P<0.05);以子宫内膜厚度和子宫内膜容积作为预测再次妊娠指标的ROC曲线下面积分别为0.714(95%CI=1.175~3.514)和0.735(95%CI=1.361~4.522)。结论复发性流产患者的子宫内膜厚度和子宫内膜容积较正常人群明显降低,子宫内膜厚度和子宫内膜容积检测能够一定程度上预测复发性流产患者的再次妊娠率。Objective To explore the correlation between re-pregnancy rateand endometrial receptivity in patients with recurrent spontaneous abortionMethods Thirty patients with recurrent spontaneous abortion were enrolledin our study from July 2016 to November 2016, and 30 patients withnormal pregnant women were selected as control group. Color Doppleultrasonography was used to detect the two groups of corpus luteum （5 to 7days after ovulation） and endometrial volume and endometrial volume, andto track the outcome of the study group of patients with pregnancy, differenoutcomes of patients with endometrial thickness and endometrial volumedifferences were compared, drawing ROC curve, uterus correlation betweenendometrial thickness and endometrial volume and recurrence rate orecurrent miscarriage. Results The endometrial thickness and endometriavolume of the control group were significantly higher than those of thestudy group （P 〈 0.05）. After 1 year follow-up, the endometrial thicknesand endometrium volume of the pregnant women in the study group weresignificantly higher than those without the second pregnancy（P 〈 0.05）The area of the ROC curve under the endometrial thickness and the volumeof the endometrium as a predictor of the second pregnancy index were0.714（95%CI=1.175~3.514）and 0.735（95%CI=1.361~4.522）. ConclusionEndometrial thickness and endometrial volume of patients with recurrenspontaneous abortion are signifcantly lower than those of normal peopleEndometrial thickness and endometrial volume are able to predict the rateof re-pregnancy in patients with recurrent spontaneous abortion.

关 键 词：复发性流产 再次妊娠 子宫内膜厚度 子宫内膜容积 超声 

分 类 号：R714.21[医药卫生—妇产科学]