大剂量丙种球蛋白联合阿司匹林治疗小儿川崎病的临床效果  

Clinical Effect of Large Dose of Gamma Globulin Combined With Aspirin in The Treatment of Children With Kawasaki Disease

作　　者：卢筱蓉[1] 

机构地区：[1]福建省龙岩市第二医院儿科,福建龙岩364000

出　　处：《中国卫生标准管理》2017年第28期108-111,共4页China Health Standard Management

摘　　要：目的分析研讨大剂量丙种球蛋白联合阿司匹林治疗小儿川崎病的临床效果。方法收集2013年2月—2017年4月收治的小儿川崎病患儿80例,用1:1随机数字法分为2组,对照组接受小剂量丙种球蛋白联合阿司匹林药物治疗,研究组接受大剂量丙种球蛋白联合阿司匹林药物治疗,比较治疗效果。结果研究组治疗总疗效92.50%高于对照组77.50%(P<0.05)。对比两组患儿症状消失时间以及住院时间,研究组均低于对照组(P<0.05)。对比两组实验室指标、血清炎性因子,治疗前差异无统计学意义(P>0.05);治疗后,研究组低于对照组(P<0.05)。结论建议临床治疗小儿川崎病给予大剂量丙种球蛋白联合阿司匹林药物,疗效优于低剂量丙种球蛋白,患儿症状以及PCT、CRP、PLT、WBC等指标改善更为明显,值得应用。Objective To analyze and discuss the clinical effect of large dose of gamma globulin combined with aspirin in the treatment of children with Kawasaki disease. Methods 80 cases of children with Kawasaki disease treated in our hospital from February 2013 to April 2017 were randomly included in the discussion, and were divided into two groups by random number method, there were 40 cases in each group. The control group was received low-dose gamma globulin combined with aspirin treatment, while the study group received high-dose gamma globulin combined with aspirin treatment. Then, the treatment condition was observed, such as symptom regression time, laboratory index and clinical effect, and were compared. Results The total clinical effect in the study group was 92.50%,which was higher than that in the control group of 77.50%（P〈0.05）.The lymph node enlargement, fever, swelling of the hands and feet, mucosal congestion and other symptoms disappeared time, and hospitalization time of two groups were compared,and the study group was lower than the control group（P〈0.05）.The laboratory indexes, serum inflammatory factors were compared between the two groups, and there was no signifcant difference before treatment（P〉0.05）.After treatment, the study group was lower than that in the control group（P〈0.05）.Conclusion The analysis suggested that the clinical treatment of children with Kawasaki disease treated with large dose of gamma globulin combined with aspirin, which its clinical effect is better than that of low-dose gamma globulin, and the improvement of children＇s symptoms, PCT, CRP, PLT, WBC and other indicators is more obvious, thus it is worthy to be applied.

关 键 词：小儿 川崎病 丙种球蛋白 阿司匹林 剂量 疗效 

分 类 号：R725.4[医药卫生—儿科]