不同剂量的纳布啡在无痛人流中抑制宫缩痛的临床研究  

Clinical Study of Different Doses of Nalbuphine in Painless in Inhibiting Uterine Contraction Pain

作　　者：李华天[1] 

机构地区：[1]吉林省延吉市延边妇幼保健院麻醉科,吉林延吉133001

出　　处：《中国继续医学教育》2018年第1期52-53,共2页China Continuing Medical Education

摘　　要：目的比较不同剂量的纳布啡与丙泊酚复合应用于无痛人流中抑制宫缩痛的效果及相关不良反应。方法 120例妇科门诊患者随机均分为三组,A组:纳布啡10 mg;B组:纳布啡20 mg;C组:纳布啡30 mg,缓慢给药,1分钟后给予丙泊酚2 mg/kg,必要时再追加丙泊酚。观察苏醒后5分钟和30分钟三组患者的视觉模拟评分(VAS评分)及相关不良反应。结果 3组苏醒后5分钟、30分钟VAS评分均小于4分,组间差异无统计学意义,呼吸抑制、恶心、呕吐发生率较低。结论纳布啡在无痛人流中抑制宫缩痛的效果确切,而且增加剂量对抑制宫缩痛无明显增幅作用,呼吸抑制、恶心、呕吐发生率低,安全性稿。Objective To compare different doses of nalbuphine and propofol used in painless in inhibiting uterine contraction pain efect and adverse reaction. Methods 120 cases of gynecologic outpatients were randomly divided into three groups. Group A nalbuphine 10 mg; group B： nalbuphine 20 mg; group C： nalbuphine 30 mg, slow delivery, 1 minute after propofol 2 mg/kg, if necessary, propofol. The visual analogue score （VAS score） and related adverse reactions were observed in three groups of patients after 5 and 30 minutes after awakening. Results The scores of VAS in the 3 groups were less than 4 scores after 5 minutes and 30 minutes, and there was no statistical diference between the groups. The incidence of respiratory depression, nausea and vomiting was lower. Conclusion Nalbuphine in painless inhibit the contraction pain efect, and increase the dose had no obvious efect on inhibiting the growth of uterine contraction pain, respiratory depression, nausea and vomiting was low, safety release.

关 键 词：纳布啡 丙泊酚 宫缩痛 

分 类 号：R614[医药卫生—麻醉学]