蔗糖铁注射液和硫酸亚铁片治疗炎症性肠病并发缺铁性贫血的疗效及安全性分析  

Clinical efficacy and safety of iron sucrose injection and ferrous sulfate tablet in the treatment of inflammatory bowel disease complicated with iron deficiency anemia

作　　者：王锦程[1,2] 

机构地区：[1]第四军医大学唐都医院,陕西西安710038 [2]西安理工大学校医院,陕西西安710032

出　　处：《临床医学研究与实践》2018年第3期13-14,共2页Clinical Research and Practice

摘　　要：目的分析蔗糖铁注射液和硫酸亚铁片治疗炎症性肠病合并缺铁性贫血的疗效及安全性。方法选择我院2012年1月至2017年3月我院收治的46例炎症性肠病合并缺铁性贫血患者为研究对象,随机分为观察组和对照组,每组23例。观察组患者静脉滴注蔗糖铁注射液,对照组口服给予硫酸亚铁片。比较两组患者治疗前、后的铁缺乏指标、血红蛋白上升20 g/L所需的时间及给药安全性。结果观察组Hb上升20 g/L所需平均时间为(11.24±1.18)d,显著短于对照组的(18.72±2.21)d(t=14.32,P<0.05)。两组患者治疗6周后的SF、TSAT、s Tf Rs水平均较治疗前显著改善,且观察组优于对照组(P<0.05)。两组患者给药后不良反应总发生率及CRP水平比较,差异不显著(P>0.05)。结论静脉铁剂相比口服铁剂能显著改善炎症性肠病合并缺铁性贫血患者的贫血及缺铁情况,且安全性较高,耐受性好,是一种值得在临床上推广使用的诊治方法。Objective To analyze the clinical efficacy and safety of iron sucrose injection and ferrous sulfate tablet in the treatment of inflammatory bowel disease complicated with iron deficiency anemia. Methods From January 2012 to March 2017, 46 cases of inflammatory bowel disease complicated with iron deficiency anemia patients in our hospital were selected as the research objects, and randomly divided into observation group and control group, with 23 cases in each group. The observation group received iron sucrose injection and the control group received oral ferrous sulfate tablet. The iron deficiency indexes levels before and after treatment, the time required for hemoglobin to rise 20 g/L and administration safety were compared between the two groups. Results The average time required for Hb to rise 20 g/L in the observation group was（11.24±1.18） d, which was significantly shorter than（18.72±2.21） d in the control group（t=14.32, P〈0.05）. The levels of SF, TSAT and s Tf Rs in both groups significantly improved after treatment for 6 weeks than before treatment, and those of the observation group were superior to the control group（P〈0.05）. The difference in the total incidence of adverse reaction after drug treating and CRP levels between the two groups was not significant（P〉0.05）. Conclusion Compared with orally taking ferrous sulfate tablet, iron sucrose injection can obviously improve the anemia and iron deficiency in patients with inflammatory bowel disease complicated with iron deficiency anemia, with higher safety and tolerance, it is a worthy method in the diagnosis and treatment in clinic.

关 键 词：炎症性肠病 缺铁性贫血 蔗糖铁注射液 硫酸亚铁 

分 类 号：R714.254[医药卫生—妇产科学]