胰岛素抵抗与心血管病理生理机制  

The pathophysiological mechanisms of insulin resistance and relative cardiovascular injury

作　　者：张静[1] 赵春江[1] 蔡辉[1] 

机构地区：[1]南京军区南京总医院中西医结合科,江苏南京210002

出　　处：《安徽医药》2018年第2期207-211,共5页Anhui Medical and Pharmaceutical Journal

摘　　要：临床研究发现,胰岛素抵抗是高血压、动脉粥样硬化、冠心病、糖尿病肾病等疾病产生的潜在危险因素。在简要分析胰岛素正常生理作用的基础上,从胰岛素抵抗对血管内皮细胞、血管平滑肌细胞和心肌细胞离子通道功能的影响三方面试析胰岛素抵抗与心血管损伤的病理生理机制,并总结提出关于胰岛素抵抗导致靶器官损害的三点基本认识:胰岛素抵抗的"蓄积"效应、"局部胰岛素抵抗效应"和"靶器官损伤差异性"。Clinical studies have shown that the insulin resistance(IR) is a potential risk factor of some cardiovascular disease,such as hypertension, atherosclerosis, coronary disease, diabetic nephropathy and so on. This article makes a brief analysis of the physiological role of insulin and then elaborates the pathophysiological mechanisms of insulin resistance and relative cardiovascular injury from the aspects of the injury pathophysiological mechanisms in vascular endothelial cell,vascular smooth muscle and cardiac muscle cell. At last,we put forward three basic views about the mechanisms between insulin resistance and the target organ's injury. These are the accumulation effects of insulin resistance,partial insulin resistance and the diversity of target organ's injury.

关 键 词：胰岛素抵抗 高胰岛素血症 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]