核-壳结构的脂质-聚合物杂化纳米粒的研究进展  

Advances in the studies of core-shell-type lipid-polymer hybrid nanoparticles

作　　者：刘丹 张军东 廉云飞 房秋雨 李娟[1] LIU Dan;ZHANG Jundong;LIAN Yunfei;FANG Qiuyu;LI Juan(School of pharmacy ,China Pharmaceutical Universi-ty ,Nanjng 211198 ,China;Haohai Biotechnology Co . Ltd ,Shanghai 201600 ,China)

机构地区：[1]中国药科大学药学院,江苏南京211198 [2]上海昊海生物科技股份有限公司,上海201600

出　　处：《药学实践杂志》2018年第1期13-17,共5页Journal of Pharmaceutical Practice

摘　　要：核-壳结构的脂质-聚合物杂化纳米粒(CSLPHNs)是以具有生物可降解性的聚合物纳米粒为核,外层包覆单层或多层具有生物膜仿生性的脂质壳而形成,结合了纳米粒和脂质体的双重优点,具有粒径小、载药量高、生物相容性好及缓控释给药等优势,在药物递送系统中应用甚广。笔者在查阅近年国内外文献的基础上归纳了CSLPHNs的基本特性、制备方法及在眼部给药、肿瘤治疗及临床诊断成像中的最新研究进展。Core-shell-type lipid-polymer hybrid nanoparticles（CSLPHNs）are composed by a biodegradable polymeric core coated with single or multiple layers of biomimetic lipids,which combine the benefits of polymeric nanoparticles and liposomes.CSLPHNs have the advantages of small particle size,high drug loading,good biocompatibility and controlled release capability.It has wide applications as a novel drug delivery system.This review gives a brief introduction in characteristics,preparation methods and applications of CSLPHNs,specifically summarizes the developments in the fields of ophthalmic drug delivery,tumor therapy and medical diagnostic imaging.

关 键 词：核-壳结构 脂质-聚合物杂化纳米粒 药物递送系统 肿瘤靶向 

分 类 号：R944[医药卫生—药剂学]