表面等离子共振技术在定量分析中的应用和研究  

Application of surface plasmon resonance biosensor in quantitative analysis research

作　　者：陈朗东 董中云 吕狄亚[3] 朱臻宇[3] 陆斌 曹岩 CHEN Langdong;DONG Zhongyun;LU Diya;ZHU Zhenyu;LU Bin;CAO Yan(Department of Pharmaceutical A - nalysis;Department of Biochemical Pharmacy;Analytical and Testing Center , School of Pharmacy , Second Military Med-ical University , Shanghai 200433 , China)

机构地区：[1]第二军医大学药学院药物分析教研室,上海200433 [2]第二军医大学药学院生化药学教研室,上海200433 [3]第二军医大学药学院分析测试中心,上海200433

出　　处：《药学实践杂志》2018年第1期18-23,共6页Journal of Pharmaceutical Practice

基　　金：国家自然科学基金(81603067;81573396)

摘　　要：表面等离子共振(surface plasmon resonance,SPR)是一种基于物质间相互作用所导致的芯片表面质量变化而产生的一种光学现象,能够简单、快速、准确地对分子间作用的强度进行动态监测。SPR生物传感器具有无标记、灵敏度高、检测结果准确、可在线实时检测等优点。SPR技术在药物发现、临床诊断、食品安全、环境监测、蛋白组学等领域都有应用。对SPR在食品卫生、环境监测、临床应用中定量分析的相关应用和研究进行综述,期望能为相关研究提供参考。Surface plasmon resonance（SPR）is an optical phenomenon arises from mass changes on sensors based on interaction between substances,which could monitor the interaction between biomolecules quickly and accurately.It has the advantage of label-free,high specificity,high accuracy,real-time and on-line monitoring,which has attracted comprehensive attention in recent years.SPR biosensors could be applied in drug discovery,clinical diagnosis,food safety,environment monitoring and proteomics.In this manuscript,the application of SPR biosensors in food safety,environment monitor and biomedical analysis have been reviewed,which could provide reference to related research.

关 键 词：表面等离子共振 定量分析 食品卫生 环境监测 生物医学分析 

分 类 号：Q81[生物学—生物工程]