昼夜节律紊乱对大鼠运动耐力、运动后血压和心率的影响  

Influence of Circadian Rhythm Disruptions on Exercise Endurance, Blood Pressure and Heart Rate after Exercise in Rats

作　　者：李一 王文竹 张玉阁[1] 申嘉怡 张通[1,5] 

机构地区：[1]首都医科大学康复医学院,北京市100068 [2]中国康复科学所中国康复医学所,北京市100068 [3]北京脑重大疾病研究院神经损伤与修复研究所,北京市100068 [4]神经损伤与康复北京市重点实验室,北京市100068 [5]中国康复研究中心北京博爱医院神经康复中心,北京市100068

出　　处：《中国康复理论与实践》2018年第1期29-36,共8页Chinese Journal of Rehabilitation Theory and Practice

基　　金：中央级公益性科研院所基本科研业务费专项资金项目(No.2017CZ-1);中国康复研究中心基金课题(No.2017ZX-4;No.2017ZX-10)~~

摘　　要：目的观察昼夜节律紊乱对大鼠运动耐力的影响。方法自发性高血压大鼠(SHR)30只和与其年龄、体质量相匹配的同源正常血压(WKY)大鼠30只,随机分为正常节律组(对照组)、12 h节律紊乱组(观察组1)、6 h节律紊乱组(观察组2),每组SHR及WKY大鼠各10只,通过改变光照/黑暗时间构建节律紊乱模型。造模前及造模后1个月、2个月和3个月分别进行一次性力竭运动试验,力竭运动后测量其血压、心率。结果 SHR大鼠造模时间与昼夜节律对力竭时间存在交互作用(F=2.409,P=0.047),造模3个月后,对照组力竭时间高于观察组1和观察组2(F=4.290,P=0.032);WKY大鼠造模时间与昼夜节律对力竭时间无交互作用(F=0.717,P=0.638),不同组间力竭时间无显著性差异(P>0.05)。造模3个月后,SHR大鼠观察组1运动后收缩压、舒张压、平均动脉压均高于对照组和观察组2(P<0.05),观察组1和观察组2运动后心率高于对照组(P<0.05);WKY大鼠不同组间运动后收缩压、舒张压、平均动脉压及心率均无显著性差异(P>0.05)。结论昼夜节律紊乱会降低SHR大鼠的运动耐力,可能与大鼠的心血管功能损伤有关。Objective To observe the influence of circadian rhythm disruptions on exercise capability in rats.Methods A total of 30 spontaneously hypertensive rats(SHR) and age and weight matched homologous normal blood pressure WKY rats were randomly divided into normal circadian rhythm group(control group), twelve hours circadian rhythm disruption group(observation group 1), six hours circadian rhythm disruption group(observation group 2). Each group included ten SHR rats and WKY rats, changing the light/dark time to construct circadian rhythm disruption model. Exercise endurance, blood pressure and heart rate after exhaustion were measured before and one, two and three months after modeling.Results The interaction of time and circadian rhythm was significant on the exhaustion time of SHR rats(F=2.409, P=0.047). After three months of modeling, the exhaustion time of the control group was more than that of the observation groups 1 and 2(F=4.290, P=0.032). The interaction of time and circadian rhythm was not significant on the exhaustion time of WKY rats(F=0.717, P=0.638), there was no significant difference in the exhaustion time among groups(P>0.05). For SHR rats, after three months of modeling, the systolic pressure, diastolic pressure and mean arterial pressure after exhaustion of the observation group 1 were higher than those of the control group and the observation group 2(P<0.05), the heart rate of the observation groups 1 and 2 was higher than that of the control group(P<0.05). But there was no significant difference in the systolic pressure, diastolic pressure,average arterial pressure and heart rate of WKY rats among groups(P>0.05).Conclusion Circadian rhythm disruptions can reduce the exercise endurance of SHR rats, which may be related to the cardiovascular function impairment.

关 键 词：高血压 昼夜节律紊乱 运动耐力 血压 心率 大鼠 

分 类 号：R54[医药卫生—心血管疾病]