Biodegradable Radiopaque Composite Filaments Based on Poly(p-dioxanone)and 2,3,5-triiodobenzoic Acid  

作　　者：徐海燕 赵帆 孙晶 王富军 王璐 

机构地区：[1]Key Laboratory of Textile Science and Technology,Ministry of Education,College of Textiles,Donghua University,Shanghai 201620,China [2]Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200082,China

出　　处：《Journal of Donghua University(English Edition)》2017年第6期741-745,共5页东华大学学报（英文版）

基　　金：Biomedical Textile Materials Science and Technolgy(111 Project),China(No.B07024);the Fundamendtal Research funds for the Central Universities,China(Samples 2232015A3-02,16D 110119);Science and Technology Support Program of Shanghai,China(No.16441903803);National Postdoctoral Foundation,China(No.2016M590299)

摘　　要：To determine the possibility of blending 2, 3, 5-triiodobenzoic acid( TIBA) and poly( p-dioxanone)( PPDO) to produce X-ray visible PPDO filaments,melt-blended PPDO with different concentrations of TIBA was obtained. Several radiopaque filaments of PPDO polymer filled with radiopaque TIBA particles were prepared via melt-blending. Material properties of the composite filaments were investigated using various material characterization techniques,including scanning electron microscope( SEM),thermogravimetric analysis( TGA),X-ray Diffraction( XRD),dynamic rheometry and micro-CT scan. In this article,the dispersion of TIBA in PPDO,the properties of the filament,and the ratio of PPDO and TIBA and the corresponding X-ray visibility in vivo were studied. SEM results showed the dispersion of the contrast imaging agent TIBA was relatively even in the PPDO polymer. Xray analysis in vitro confirmed the enhanced radiopacity of the filaments with respect to the pure PPDO filament. The presence of iodine element in the composite filament could allow the bioabsorbable material to be monitored in vivo, and made it potential to be used in biomedical applications.To determine the possibility of blending 2, 3, 5- triiodobenzoic acid （TIBA） and poly（p-dioxanone） （PPDO） to produce X-ray visible PPDO filaments, melt-blended PPDO with different concentrations of TIBA was obtained. Several radiopaque filaments of PPDO polymer rifled with radiopaque TIBA particles were prepared v/a melt-blending. Material properties of the composite filaments were investigated nging various material characterization techniques, including scanning electron microscope （SEM）, thermogravimetric analysis （ TGA ）, X-ray Diffraction （ XRD）, dynamic rheometry and miero.CT scan. In this article, the dispersion of TIBA in PPDO, the properties of the filament, and the ratio of PPDO and TIBA and the corresponding X-ray visibility in vivo were studied. SEM results showed the dispersion of the contrast imaging agent TIBA was relatively even in the PPDO polymer. X- ray analysis in vitro confirmed the enhanced radiopacity of the filaments with respect to the pure PPDO filament. The presence of iodine dement in the composite filament could allow the bioabsorbable material to be monitored /n vivo, and made it potential to be used in biomedical applications.

关 键 词：poly(p-dioxanone)(PPDO) 2 3 5-triiodobenzoic acid(TIBA) melt-blending radiopaque filament 

分 类 号：N0[自然科学总论—科学技术哲学]