Surface Modification of Polyglycolic Acid Fibers by Hydrogen Peroxide for Enhancing Hydrophilicity and Cytocompatibility  

作　　者：王碧峤 张佩华 赵莉 何晨光 

机构地区：[1]College of Textile and Clothing,Dezhou University,Dezhou 253023,China [2]College of Textiles,Donghaa University,Shanghai 201620,China [3]Shanghai Jurui Biomaterials Limited Company,Shanghai 200241,China

出　　处：《Journal of Donghua University(English Edition)》2017年第6期768-773,共6页东华大学学报（英文版）

基　　金：Shanghai Science and Technical Committee,China(No.10411953300);State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,China(No.LZ0902);Minhang District Industry-Study-Research Cooperation,China(No.2012MH202)

摘　　要：Hydrogen peroxide( H_2O_2) is applied for surface modification of polyglycolic acid( PGA) fibers in order to enhance the hydrophilicity and cytocompatibility of PGA fibers effectively,and maintain the breaking strength as the same time. PGA fibers are dipped in H_2O_2 solution a certain time for modification. Scanning electron microscopy( SEM) was used to observe the surface morphology of PGA fibers before and after modification. The varying of PGA macromolecule was examined with Fourier transform infrared spectroscopy( FTIR) analyses. X-ray diffraction( XRD) and differential scanning calorimetry( DSC) analysis showed that crystallinity slightly decreases. Mechanical performance test showed tensile force of modified PGA fiber was increased. The water contact angle test indicated the improving of hydrophilic. A cell proliferation assay showed that fibroblast cells attach and proliferate well on the fibers, which meant the modified fibers possess good cytocompatibility. These results suggest that H_2O_2 surface modification is easy to operate and a advantageous modification method for PGA fibers.Hydrogen peroxide （H2O2 ） is applied for surface modification of polyglycolic acid （PGA） fibers in order to enhance the hydrophilicity and cytocompatibility of PGA fibers effectively, and maintain the breaking strength as the same time. PGA fibers are dipped in H2O2 solution a certain time for modification. Scanning electron microscopy （SEM） was used to observe the surface morphology of PGA fibers before and after modification. The varying of PGA macromolecule was examined with Fourier transform infrared spectroscopy （FTIR） analyses. X-ray diffraction （ XRD ） and differential scanning calorimetry （ DSC ） analysis showed that crystallinity slightly decreases. Mechanical performance test showed tensile force of modified PGA fiber was increased. The water contact angle test indicated the improving of hydrophilic. A cell proliferation assay showed that fibroblast cells attach and proliferate well on the fibers, which meant the modified fibers possess good cytocompatibility. These results suggest that H2O2 surface modification is easy to operate and a advantageous modification method for PGA fibers.

关 键 词：polyglycolic acid(PGA) hydrogen peroxide（H2O2） surface modification HYDROPHILICITY CYTOCOMPATIBILITY 

分 类 号：N0[自然科学总论—科学技术哲学]