多潘立酮胶囊联合替普瑞酮对慢性萎缩性胃炎伴肠上皮化生患者的临床研究  

Clinical trial of doperridone capsule combined with tipurone in the treatment of patients with chronic atrophic gastritis and intestinal metaplasia

作　　者：郭明浩[1] 戴明[2] 郭遂成[1] 

机构地区：[1]南阳医学高等专科学校第一附属医院普外科,河南南阳473000 [2]新疆医科大学中医学院,乌鲁木齐830011

出　　处：《中国临床药理学杂志》2018年第2期99-101,共3页The Chinese Journal of Clinical Pharmacology

基　　金：新疆维吾尔自治区自然科学基金资助项目(2016D01C178)

摘　　要：目的观察多潘立酮胶囊联合替普瑞酮对慢性萎缩性胃炎伴肠上皮化生患者的临床疗效。方法将86例慢性萎缩性胃炎伴肠上皮化生患者分为对照组和试验组,每组43例。对照组给予多潘立酮10 mg,tid,口服,持续治疗8周。试验组在对照组的基础上给予替普瑞酮50 mg,tid,口服,持续治疗8周。观察2组患者的临床疗效、症状积分、肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)、胃蛋白酶原Ⅰ/胃蛋白酶原Ⅱ(PGR)及药物不良反应发生情况。结果治疗后,试验组和对照组总有效率分别为90.70%(39例/43例)和72.09%(31例/43例),差异有统计学意义(P<0.05)。试验组和对照组症状积分分别为(8.48±1.15),(12.64±1.65)分,TNF-α分别为(1.13±0.15),(1.88±0.26)mg·L^(-1),IL-8分别为(7.62±0.94),(8.86±1.80)ng·L^(-1),PGR分别为27.16±4.07,22.40±2.68,差异均有统计学意义(均P<0.05)。2组均有腹痛、恶心、口干、头昏发生,对照组和试验组的药物不良反应率分别为18.60%(8例/43例)和9.30%(4例/43例),差异无统计学意义(P>0.05)。结论多潘立酮胶囊联合替普瑞酮对慢性萎缩性胃炎伴肠化患者的疗效确切,能够有效调节TNF-α、IL-8水平,提高PGR。Objective To evaluate the clinical effect of doperridone capsule combined with tipurone in the treatment of chronic atrophic gas- tritis with intestinal metaplasia. Methods Eight - six patients with chro- nic atrophic gastritis and intestinal metaplasia were divided into control group and treatment group, each group 43 cases. Control group was trea- ted with doperridone capsule 10 rag, tid, oral. Treatment group was trea- ted with tipurone 50 mg on the basis of control group, tid, oral. All the patients were treated for 8 weeks. The clinical effect, symptom score, tumor necrosis factor - ct （ TNF - cx）, interleukin - 8 （ IL - 8 ）, pepsino- gen I/pepsinogen 1I （PGR） , and adverse drug reactions in two groups were observed. Results After treatment, total effective rates of treat- ment group and control group were 90. 70% （39 cases/43 cases ）, 72.09% （31 cases/43 cases）, with significant difference （P 〈 0. 05 Symptom score of treatment group and control group were 8.48 ± 1.1 12. 64 ±1.65, TNF-ot were （1.13 ±0. 15）, （1.88 ±0. 26）mg · L-1, IL- 8 were （7.62 ±0.94）, （8.86 ± 1.80）ng · L-l, PGR were27. 16 ±4. 07, 22.40 ±2. 68, all with significant difference（ all P 〈0. 05）. The adverse drug reactions in two groups were abdominal pain, nausea, dry mouth and dizziness, the incidence of adverse drug reactions in control group and treatment group were 18. 60% （ 8 cases/43 cases ） and 9. 30% （4 cases/43 cases）, with no statistical difference （ P 〉 0. 05 ）. Collusion Clinical effect of doperridone capsule combined with tipurone in the treatment of chronic atrophic gastritis with intestinal metaplasia is better than tipurone alone, can effectively adjust the levels of TNF -a and IL - 8. improve PGR.

关 键 词：慢性萎缩性胃炎 肠上皮化生 多潘立酮胶囊 替普瑞酮 肿瘤坏死因子-α 白细胞介素-8 胃蛋白酶原Ⅰ/胃蛋白酶原Ⅱ 

分 类 号：R975[医药卫生—药品]