主动脉夹层患者高密度脂蛋白亚类功能变化研究  

Functional Changes of High Density Lipoprotein Subclass in Patients With Aortic Dissection

作　　者：王振坤 李鹏[2] 聂炳荣 刘辰 何婧 

机构地区：[1]珠海市第二人民医院心血管内科,广东省519000 [2]中山大学第五附属医院老年医学科

出　　处：《中国循环杂志》2018年第1期92-95,共4页Chinese Circulation Journal

摘　　要：目的 :观察主动脉夹层急性患者高密度脂蛋白(HDL)亚类功能变化并探讨其临床意义。方法 :分别选择60例急性主动脉夹层患者(主动脉夹层组)及60名健康体检者(健康对照组),检测两组受试者血脂四项、高密度脂蛋白亚类(HDL2,HDL3)、巨噬细胞[3H]胆固醇转出率、细胞间黏附分子1(ICAM-1)及血管内细胞黏附因子1(IVCAM-1)、对氧磷脂酶1(PON1)水平变化。结果:与健康对照组相比,主动脉夹层组HDL2水平降低[(41.15±19.02)mmol/L vs(60.48±22.19)mmol/L,P=0.010],HDL3水平升高[(58.85±29.97)mmol/L vs(39.52±30.15)mmol/L,P=0.013];巨噬细胞[3H]胆固醇转出率[(5.79±0.97)%vs(11.45±2.15)%,P<0.01]、PON1活性[(125.62±9.90)μ/ml vs(158.72±13.27)μ/ml,P<0.01]均较低,而ICAM-1平均荧光强度[(33 571.85±2 529.97)vs(17 239.52±4 330.15)]及IVCAM-1平均荧光强度[(442.15±119.02)vs(260.48±92.19]均较高,差异均有统计学意义(P<0.05)。结论:主动脉夹层患者HDL亚类促胆固醇逆转运、抗炎及抗氧化功能受到损害,均较健康人群明显减弱。Objective： To observe the functional changes of high density lipoprotein（HDL） subclass in patients with aortic dissection and to explore its clinical significance.Methods： Our research included in 2 groups： Aortic dissection group, n=60 patients and Control group, n=60 healthy subjects from regular physical examination. Blood levels of lipids, HDL subclass of HDL2 and HDL3, macrophage [^3H] cholesterol efflux rate, intercellular adhesion molecule-1（ICAM-1）, intravascular cellular adhesion molecule-1（IVCAM-1） and paraoxonase 1（PON-1） activity were examined and compared between 2 groups.Results： Compared with Control group, Aortic dissection group had reduced HDL2 level（41.15±19.02） mmol/L vs（60.48±22.19） mmol/L, P =0.010 and elevated HDL3 level（58.85±29.97） mmol/L vs（39.52±30.15） mmol/L, P =0.013; decreased macrophage [-3H] cholesterol efflux rate（5.79±0.97） % vs（11.45±2.15） %, P〈0.01 and decreased PON-l activity（125.62±9.90） μ/ml vs（158.72±13.27） μ/ml, P〈0.01; increased expressions of ICAM-1（33 571.85±2 529.97） vs（17 239.52±4 330.15） and IVCAM-1（442.15±119.02） vs（260.48±92.19） by fluorescence intensity, both P〈0.05.Conclusion： Aortic dissection patients showed damaged HDL subclass reverse cholesterol transportation function and antioxidative function, both of them were lower than healthy population.

关 键 词：主动脉瘤 脂蛋白类 HDL 

分 类 号：R541[医药卫生—心血管疾病]