妇乐颗粒治疗急性盆腔炎患者的临床效果及对hs-CRP,PCT,IL-2,IL-10水平的影响  

Research on the Clinical Effect and Influence of Hs-CRP,PCT,IL-2 and IL-10 Levels for Treating Acute Pelvic Inflammatory Disease with Fule Granules

作　　者：徐慧敏 杨波 朱亚芹 王家俊[2] 

机构地区：[1]无锡市惠山区第二人民医院妇产科,无锡214187 [2]无锡市妇幼保健院妇科,无锡214023

出　　处：《世界中医药》2017年第12期2908-2911,共4页World Chinese Medicine

基　　金：江苏省卫计委妇幼保健重点项目(F201522)

摘　　要：目的:探讨妇乐颗粒治疗急性盆腔炎患者的临床效果及对hs-CRP,PCT,IL-2,IL-10水平的影响。方法:将收治的112例急性盆腔炎性患者按照随机数字表法分为对照组和观察组,各56例。对照组患者给予替硝唑注射液静脉滴注,观察组患者则加用妇乐颗粒治疗,连续治疗4周。比较2组的有效率,评价中医证候积分,记录主要症状的消失时间,监测治疗前后细胞因子水平变化。结果:观察组患者的有效率91.1%明显高于对照组患者的75.0%,差异有统计学意义(P<0.05);治疗后观察组患者主要症状的中医证候积分明显低于治疗前及对照组,差异有统计学意义(P<0.05);观察组患者经治疗后主要症状缓解更快,差异有统计学意义(P<0.05);治疗后观察组hs-CRP,PCT水平显著低于对照组,而IL-2,IL-10则明显高于对照组,差异有统计学意义(P<0.05)。结论:妇乐颗粒治疗急性盆腔炎疗效突出,利于改善临床症状,缩短病程,这与妇乐颗粒可调控血清细胞因子水平,从而明显降低急性盆腔炎患者机体炎性反应有一定相关性。Objective： To investigate the clinical efficacy and Influence of hs-CRP,PCT,IL-2 and IL-10 levels for treating acute pelvic inflammatory disease with fule granules. Methods： One hundred and twelve patients were randomly divided into a control group of 56 cases and an observation group of 56 cases. Patients in the control group were treated with indications for injection intravenous drip; while patients in the observation group were treated with fule granules,four weeks for treatment. The research was focus on comparing the effectiveness,evaluating its syndrome integral,recording the disappear time of main symptoms and testing the levels change of inflammatory factors. Results： The efficiency for patients in the observation group was 91. 1%,which was higher than that of the control group 75. 0%,difference was very remarkable（ P〈0. 05）; The TCM syndrome integrals for patients in the observation group were lower than that of the control group,difference was very remarkable（ P〈0. 05）; The disappear time of main symptoms for patients in the observation group were less than that of the control group,difference was very remarkable（ P〈0. 05）;The levels of hs-CRP and PCT for patients in the observation group were lower than that of the control group after treatment（ P〈0. 05）; while the level of IL-2 and IL-10 for patients in the observation group was higher than that of the control group after treatment（ P〈0. 05）. Conclusion： The therapy has good effect,it can improve the patients＇ clinical symptoms and shorten the duration of symptoms. The mechanism may be associated with the regulation of cytokines levels in the blood to reduce the body＇s inflammatory response in patients with acute pelvic inflammatory disease,is worthy of further research and development.

关 键 词：急性盆腔炎 妇乐颗粒 炎性因子 临床研究 

分 类 号：R289.5[医药卫生—方剂学] R271[医药卫生—中药学]